The flashcards below were created by user abbyljones9 on FreezingBlue Flashcards.

  1. infrared spectroscopy
    the study of the reflected, absorbed, or transmitted radiant energy in that region of the electromagnetic spectrum from wavelength 0.8 to 500um
  2. frequency
    the number of waves per unit length
  3. polymorphism
    change in the crystaline structure due to grinding
  4. Which cateegory of drugs does polymorphism primarily affect?
  5. What molecular interactions are the bases for infrared spectroscopy?
    dipole moments
  6. ATR stands for
    attenuated total reflection
  7. FT in FTIR stands for
    fourier transform
  8. Why is potassium bromide (KBr) used in the IR analysis of drugs?
    KBr does not absorb within in the mid-IR region
  9. IR absorption only occurs where a change of the ________ ________ of the molecule can take place.
    dipole moment
  10. What is evanescent?
    A series of reflective absorptive interactions; multiple internal reflections
  11. Name 3 sample preparation techniques that can be used for liquid and solid samples.
    • on KBr disk or "neat"
    • ATR
    • liquid film
  12. Name the 3 regions within the IR spectrum.
    • Near infared
    • Mid-infared
    • Far-infared
  13. Which region within the IR spectrum is used in the IR analysis of drugs?
  14. Name the 2 sub-regions within the mid-infared region.
    • Group frequency region
    • Fingerprint region
  15. ___________ bands are the primary absorption bands for each mode of vibration.
  16. ____________ bands occur at multiples of the fundamental bands.
  17. ___________ bands occur at wavelengths that are the sum or difference of 2 or more fundamental bands.
  18. _____________ bands are the strongest of the 3.
  19. Give the formula for calculating wavenumber (v) from the wavelength.
    Wavenumber(v) = 104 / Wavelength
  20. In what units are wavenumber (v) and wavelength expressed?
    v = cm-1 or reciprocal centimeters

    Wavelength = u (microns)
  21. What are 2 reasons you might use KCl instead of KBr for IR sample preparation?
    KCl is less hygroscopic

    chemical changes
  22. What is the major difference between a dispersive IR and an FTIR ( with an interferometer)?
    monochromator vs interferometer
  23. True or False

    Diatomic molecules (such as H2, N2, & O2) do not absorb in the infrared region.
  24. True or False

    IR cannot be used to distinguish between diastereomers.

    it can be used
  25. True or False

    For forensic drug analysis, the IR region that is typically scanned is from 4000 - 400cm-1.
  26. True or False

    IR is a highly characteristic property that can be used for identity and structural elucidation.
  27. True or False

    IR spectra can only be obtained from liquid and solid samples.

    can be obtained from liquid, solid, & gas
  28. Name the 5 parts of the interferometer.
    • Source
    • Moveable mirror
    • Fixed mirror
    • Beam splitter
    • Detector
Card Set
Drug Analysis
Show Answers