Meeting 2

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plasma membrane (any membrane)
- has 2 functions:
- 1) to act as a barrier
- 2) but things have to pass through/be transported through as well...this is what proteins are good for
lipid-anchor protein
- polypeptides of interest aren’t hydrophobic in any
- way but attach to the membrane using lipid anchors; anchors don’t span whole membrane; the peptides are functional only on ONE side of membrane
peripheral membrane protein

not covalently bonded to membrane; located at and are functional at the membrane; attached via weak interactions w/ head groups
integral membrane protein
- proteins that span the whole membrane and bridge between the 2 sides; essential for bridging exoplasmic & cytoplasmic
- -have both hydrophobic (for internal) and hydrophilic residues (to interact w/ head groups)
hydrophobic amino acids:
- aliphatic (cyclic) ones are extremely hydrophobic (3 out of the 8); these are the ones that can interact with fatty acids (especially cholesterol)
- -basically all those CH₃'s are good for fatty acid interactions
micelle's v. liposomes

micelle's have no internal acques compartment; liposomes do