Clinical Trials in Neurology
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The study which showed that ASA was not inferior to Heparinin the secondary prevention of stroke in the setting of atrial fibrillation (acute)
- HAEST - Heparin in Acute Embolic Stroke Trial
RCT of 449 pts with AF and acute ischemic stroke comparing Dalteparin 100 IU/kg SC BID vs. ASA 160 mg QDAY
- No difference in recurrent stroke after 14 days
- or death at 3m
The study which showed ASA was not inferior to Warfarin in the prevention of stroke
2206 patients with noncardioembolic ischemic stroke randomized to Warfarin vs. ASA 325mg
No difference in death or recurrent stroke after 2 yrs
The study which showed that showed ASA was as good as and associated with a lower risk of bleeding than Warfarin in the treatment of intracranial stenogis.
RCT of 569 patients with intracranial stenosis by angio or MRA randomized to Warfarin vs. ASA 1300mg/
No difference + more bleeding in warfarin group
The study which demonstrated that IM Midazolam was not inferior to IV Lorazepam in the acute treatment of status epilepticus
Demonstrated a reduction in stroke risk from 2 to 1% in asymptomatic patients with >60% stenosis who underwent surgery
ACAS - Asymptomatic Carotid Atherosclerosis Study
Demonstrated the benefit of CEA over medical management in symptomatic patients with >70% stenosis with some benefit in patients with a 50 - 70% stenosis.
NASCET - North American Symptomatic Carotid Endarterectomy Trial
The study which established TPA as the standard of care
The study which addressed the importance of blood pressure control in ICH
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