Pharm 430B

Card Set Information

Author:
jaguavai
ID:
137214
Filename:
Pharm 430B
Updated:
2012-02-23 16:15:03
Tags:
430B Roseman 2014
Folders:

Description:
Druggy goodness
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  1. Filler/diluent (2)
    • lactose
    • Microcrystalline cellulose
  2. Binders (3)
    • Starch PASTE
    • Gelatin solution
    • Hypromellose
  3. Disintegrants (2)
    • Starch
    • Croscarmellose
  4. Lubricants (2)
    • Mag. stearate
    • Poly(ethyleneglycol)
  5. Glidant (2)
    • Colloidal silicon dioxide
    • Talc
  6. Too much lube leads to
    Decreased dissolution
  7. Too much diluent leads to
    • INCREASED dissolution
    • (believed to increase surface area of granules, leading to more rapid dissolution)
  8. Too much granulating agents or binders leads to
    Enhanced dissolution. Gelatin imparts hydrophilic character to drug
  9. Too much compression force leads to
    increased wettability, improved dissolution
  10. Osmogens (4)
    • Mannitol
    • Lactose
    • KCl
    • NaCl
  11. Enteric coating, most common
    Cellulose acetate phthalate (also non-aqueous film coating)
  12. Lozenges diluents (3)
    • Glucose
    • Sorbitol
    • Mannitol
  13. Carr's Index to determine flow properties
    [(tapped density-poured density)/tapped density] X 100
  14. Angle of repose
    Inverse tangent of height of cone/RADIUS of cone
  15. Spatulation
    Not suitable for large quantities, good for eutectic mixtures
  16. Trituration
    geometric dilution
  17. Euctectic mixtures
    when mixed, may liquify
  18. Efflorescent powders
    • crystalling in nature with water in crystal
    • water may release during mixing, powder sticky
  19. Capsules - most commonly used plasticizer
    glycerol
  20. Softgel preservatives are
    bens. Parabens, etc.
  21. Capsule fill weight formula
    tapped bulk density of formula X capsule volume
  22. Moist heat (autoclave)
    • Heat and pressure
    • Used for iv bags, rubber stoppers, bottles, administration sets
  23. Dry heat
    • Containers
    • Instruments
    • Fixed oils, petrolatum, mineral oil, paraffin
  24. Gas sterilization
    • ethylene ozide, propylene oxide
    • Some drug powders
    • Administration sets, needles, syringes IN CARDBOARD
  25. Filtration
    only for solutions
  26. Radiation
    air and surfaces

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