Autonomic Drugs- Cholinomimetic

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  1. Amphetamine
    sympathomimetic drug that facilitates the release of catecholamines from adrenergic nerve endings
  2. Vesamicol
    inhibit uptake of Ach into transmitter vesicles of cholinergic nerve
  3. Hemicholinium
    inhibit the transport of choline into the nerve terminal
  4. Botulinum toxin
    Bacterial toxin that enzymatically disables release of acetylcholine from cholinergic nerve endings
  5. Cocaine
    Drug that impairs reuptake of catecholamine transmitters (NE, dopamine) by adrenergic nerve endings
  6. Dopamine
    renal vasodilation, CNS
  7. Epinephrine
    neurotransmitter in CNS
  8. Reserpine
    drug that inhibits uptake of dopamine and NE into transmitter vesicles of adrenergic nerves
  9. Guanethidine
    inhibits release of dopamine and NE from adrenergic nerve terminal
  10. Bethanechol
    Activates your Bowels and Bladder
    Activate muscarinic R mainly
    • Clinical Use: Postoperative and neurogenic ileus and urinary retention
    • resistant to AChE
  11. Carbachol
    Activate muscarinic R mainly
    Glaucoma, pupillary contraction, and relief of intraocular pressure
  12. Pilocarpine
    you cry, drool, and sweat on your PILOw
    Activate muscarinic R mainly
    • Potent stimulator of sweat, tears, saliva
    • resistant to AChE
  13. Methacholine
    Activate muscarinic R mainly
    Use: Challenge test for diagnosis of asthma
  14. Neostigmine
    NEO CNS= NO CNS penetration
    activate muscrinic and nicotinic R
    postoperative and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular junction blockade (postoperative)
  15. Pyridostigmine
    gets RID of MG
    activate muscrinic and nicotinic R
    myasthenia gravis (long acting)
  16. Edrophonium
    activate muscrinic and nicotinic R
    diagnosis of myasthenia gravis
  17. physostigmine
    activate muscrinic and nicotinic R
    Glaucoma (crosses blood-brain barrier --> CNS) and atropine overdose
  18. Echothiophate
  19. Donepezil, rivastigmine, galantamine, tacrine
    Alzheimer's disease
  20. Cholinesterase Inhibitor Poisoning
    • organophosphates: parathion that irreversibly inhibit AchE. "-thion", malathion, Sarin & tabun (nerve gases; terrorist threat)
    • Diarrhea
    • Urination
    • Miosis
    • Bronchospasm
    • Bradycardia
    • Excitation of skeletal muscle and CNS
    • Lacrimation
    • Sweating
    • Salivation
    • Antidote- atropine + pralidoxime(regenerates active AchE)
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Autonomic Drugs- Cholinomimetic
2012-02-28 05:02:29

Autonomic Drugs- Cholinomimetic
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