Ondansetron (Zofran)

  1. Class
    Antiemetic
  2. Description
    Serotonin Antagonist
  3. Mechanism of Action
    Blocks serotonin receptors in the CTZ, stomach and small intestine.
  4. Onset of Action
    • Onset: 10-30 min
    • Peak: 1.5 hrs
    • Duration: 8 hrs
    • Half-life: 3 hrs
  5. Indications
    nausea, vomiting
  6. Contraindications
    Known Hypersensitivity
  7. Precautions/ Side Effects
    • Patients taking other serotonin blockers
    • Rifampin reduces effects
    • Headache
    • light headedness
    • dizziness
    • tiredness
    • constipation
  8. Adult Dose
    4-8mg
  9. Pedi Dose
    0.15mg/kg
  10. Max Dose
    NONE
  11. Route of Administration
    IV, PO, IM (last resort)
  12. How Supplied
    Vials, 4mg and 8mg tablets
Author
Kgren
ID
138045
Card Set
Ondansetron (Zofran)
Description
Ondansetron (Zofran)
Updated