Med chem

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ANVigil
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138585
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Med chem
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2012-03-01 19:28:47
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  1. Isolated from poppy
    US goverment largester purchaser
    Narcotic Analgesic used in CHF
    Eases Mind
    Morphine
  2. Isolated from bark
    Antimalarial
    R,S
    Quinine
  3. (S,S) diastereomer
    Anti-arrhythmic agent
    Quinidine
  4. Anticancer drug
    Isolated from Cantharanthus roseus
    Vinblastine
  5. Anticholinergic agent
    Belladonna alkaloid
    Dry up secretions
    Atropine
  6. Isolated from foxglove
    Iontropic agent
    Strengthens heart muscle contractions
    Cardiac glycoside (steroid sugar)
    Key drug in CHF
    Narrow Theraputic Index
    Digitoxin
  7. Isolated from Pacific Yew Tree but fungus of importance
    Produced by fermentation and semi-syntheically
    Anticancer for ovarian and breast cancers
    Taxol (paclitaxel)
  8. Isolated from Podophyllum peltatum
    Anticancer
    spindle inhibitor
    Etoposide
  9. Isolated from Colchicum autamnale
    Anti-inflammatory off label use post cardiac surger
    Treats Gout
    Spindle inhibitor
  10. Colchicine
  11. Isolated from willow bark
    Analgesic
    Decreases stickiness in platelets in low dose
    Acetyl salicylic acid
  12. Class of drugs that are derivatives of carbohydrates
    • Antibacterials
    • Streptomycin, Neomycin, Gentamicin, Kanamicin
  13. Anticoagulant
    Polysaccharide
    Sulfated in a number of positions
    IV administration
    Prevent thrombosis
    Isolated from pig and cow long and gut linging
    Involves serine protease clotting factors and the serine protease inhibitor antithrombin III
    Metabolized from liver
    Monitor
    Sodium Heparin
  14. Medicinally usefull sugar alchol
    Food, cosmetic, pharmaceutical (sweeting) 70% w/w
    Reduction of open chain form of D-glucose
    Sorbitol
  15. Medicinally useful sugar alchol
    Osmotic diuretic that increases the osmotic gradient in the kidney, also an excipient (no hydroscopic)
    Mannitol (Osmitrol)
  16. Medicinally useful sugar
    D-Glucose (mixture of alpha and beta)
    Obtained by hydrolysis of starch, fluid and nutrient replenisher
    Dextrose
  17. Medicinally useful sugar
    Calcium replenisher
    oral, IM, IV
    Calcium gluconate
  18. Medicinally useful sugar
    Iron supplement
    Oral or IV
    Ferrous Gluconate
  19. Medicinally useful sugar
    Lactone version marketed as glucurone
    Useful for certain arthritc conditions
    D-Glucuronic acid
  20. Carbohydrate used as fluid replenisher and nutrient
    Fructose
  21. Pharmaceutic aid used for tablet and capsule diluent (milk sugar)
    Don't use in people with lactose intolerance
    Lactose
  22. Pharmaceutical aid for sweeting and tablet excipient
    From cane sugar and beet sugar
    A disaccharide that yields one D-glucose and one D-fructose on hydrolysis
    Sucrose
  23. Variable molecular weight polysaccharides obtained by enzymatic hydrolysis of startch
    Used as carbohydrate sourse in formulas
    Dextrins
  24. Malt sugar obtain by enzymatic digestion of starch to disacchardie of D-glucose
    Extensively used as carbohydrate soureces in formulas
    Maltose
  25. used as a diagnostic aid to test intestinal capcity to detect celiac disease
    Xylose
  26. Amylum
    Isolated from corn and is a hight molecular weight carbohydrate
    10-20% amylose
    80-90% amylopectin
    Sugar bon innkages are alpha 1,4
    Used as an absorbent, an emollient, and in tablets and capsules
    Starch NF
  27. modiefied starch for use as a tablet excipient
    Pregelatinized starch
  28. A polysaccharide that utilizes beta-1,4 glycosidic linkages to hook together 100 to 200 beta-D-glucose molecules
    Most often found in plants as supporting structures
    Humans can't digest
    Cellulose and derivatives
  29. Surgical aid
    Cellulose product
    Purified cotton
  30. Pharmaceutical tablet diluent
    cellulose product
    Microcrystalline cellulose
  31. Pharmaceutical tablet diluent, adsorbant, suspending agents
    cellulose product
    Powdered Cellulose
  32. Swells upon water addition
    Suspending agent, tablet excipent, viscosity increasing agent, bulk laxative, thickening agent
    Ophthalmic solutions-topically protectant contract lenses
    cathartic
    cellulose product
    Methyl cellulose
  33. Pharmaceutical tablet binder
    cellulose product
    Ethyl cellulose
  34. suspending agent, tablet excipent, viscosity increasing agent
    ophthalmic solutions
    cellulose product
    Hydroxypropylcellulose
  35. Local hemostatic to control hemorrhage
    cellulose products
    Oxidized cellulose
  36. Suspending agents, tablet excipent, viscosity increasing agent
    Tablets-cathartic
    emollient type bulk laxative with excellent lubricating properties
    cellulose product
    Used in constipation
    Carbosymethylcellulose Sodium
  37. Needed to produce Collodion
    gun cottom by treating cotton with nitric and sulfuric acid to produce cellulose tetranitrate
    used for various coating purposes
    Pyroxylin
  38. Tablet coating agent
    soluble in the alkaline environment of the intestinal tract
    Cellulose acetate phthalate
  39. Antidote for heparin sodium overdose
    Protamine sulfate
  40. Low-Molecular Weight Heparin Products
    • Ardeparin Sodium (Normiflo)
    • Dalteparin Sodium (Fragmin)
    • Enoxaprin Sodium (Lovenox)
    • Danaparoid Sodium (Orgaran)
  41. alpha-Glucosidase inhibitor
    Inhibits the enzymes responsible for the hydrolysis of detrin carbohydrates in the intestinal tract thereby delaying their digestion
    Used in the adjuct treatment of diabetes mellitus
    Acarbose (Precose)
  42. Topical treatment of acne in a cream, initially acne is worse but improves over 3-4 weeks with skin peeling
    USE SUNSCREEN
    MoA: Decreases adhesion of corneocytes, increase proliferation of follicular epithelium
    Also used for APL (Acute Promyelocytic Leukemia) treatment Anticancer drug
    Vitamin A product
    Tretinoin (Retin-A)
  43. Used for treatment of severe acne as capsules dose form
    Corse of terapy is 15-20 weeks
    MoA: Inhibits sebaceous gland function and follicular function decreasing sebum production and gland size and differentiation
    Advers effects mimic chronic hypervitaminosis A
    Women tested for pregnancy before hand
    Requires effective birth control during course of therapy
    Tetratogenic
    Vitamin A product
    Isotretinoin (Accutane)
  44. Used for the treatment of severe recalcitrant psoriasis
    available as a capsule dosage form
    significant first-pass effect, long term storage in adipose dissue
    Can be detect up to a year after discontinuation
    Tetratogenic
    Tested for pregnancy before
    Must use birthcontrol during and for a time after therapy
    Vitamin A product
    Etretinate (Tegison)
  45. How vitamin D is put in milk
    Vitamin D2
    Ergocalciferol (Calciferol, Drisdol)
  46. Vitmin D3
    Cholescalciferol (Delta-D)
  47. Vitamin D derivative
    Dihydrotachysterol (DHT)
  48. Used in patients that are recieving long-term renal dialysis
    Vitamin D
    Calcifediol (Calderol)
  49. Used for patients that are recieving long-term renal dialysis or patients that can not properly metabolize vitamin D2
    Does not need metabolic activation
    Calcitrol (Rocaltrol, Calcijex)
  50. Topical cream synthetic vitamin D analong used in moderate plaque psoriasis
    100-200 times less effect on calcium metabolism
    reduces cell numbers and total DNA content by inhibting epidermal cell proliferation and enhances cell differentiation
    same affinity for Vitamin D receptor
    Calciptriene (Dovonex, Westwood Squibb)
  51. Vitamin E indicated in
    • Low serumen tocopherol levels
    • Increase gragility of RBC
    • Inschemic heart disease
    • Atherosclerosis
  52. Systemic hemostatic agent based on its critcal function in blood coagulation
    Treatment of hypoprothrombinemia cuased by malabsorption or died deficiency
    Used to attempt to counter the bleeding caused by coumarin type anticoagulants
    Oral, SC, IM or slow IV infusion
    Prodces rapid prolong effect
    Given to newborns after birth
    Vitamin K product
    Phytonadione (Mephyton, AquaMephyton)
  53. Vitamin K product
    Equally potent to vitamin K on mole for mole basis
    Must be converted by the liver to Vitamin K using geranylgeranylpyrophosphate
    Effective orally, IV and IM
    IF biliary obstuction then give with bile salt
    IM administration is done using oil to give prolonged effect
    Menadione (Vitamin K3)
  54. B Vitamins
    • Thiamine
    • Riboflavin
    • Prridoxin
    • Nicotinic acid
    • Pantothenic acid
    • Biotin
    • Cyanocobalamin
    • Folic acid
  55. Thiamine (B1) Deficiency leads to?
    • Beriberi
    • Wernickes' encephelopathy
    • Korsakoff psychosis
  56. Thiamine (B1) found in?
    cereals, brans, egg yolks, yeast extracts, peases, beans, nuts
  57. Mega-dose of thiamine (B1)?
    have not been associated with adverse health effects and excess of the water soluble vitamin is excreted
  58. Liver, eggs, cereals can provide this in the form of CoEnzyme A
    CoEnzyme A is not absorbable in the gut so it must be hydrolyzed and absorbed by passive diggusion
    Circulates in the body as pantothenate where it is absorbed into the cell and converted to CoA
    Pantothenic acid (Vitamin B5)
  59. Megadose of Pantothenic acid (B5)
    Diarrhea
  60. symptoms of Nicotinic acids (B3) deficiency?
    • Diarrhea, Dermatitis, Demetitis
    • Death
  61. Niacin deficiency leads to?
    Pellegra
  62. What is ariboflavionosis
    Deficiency with sevorrheic dermatitis and vascularization of the cornea, can result from three drugs previously mention and chronic alcoholism

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