S2M2 biochem

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sweetlu
ID:
138653
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S2M2 biochem
Updated:
2012-03-12 16:26:28
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S2M2 biochem
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S2M2 biochem
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  1. Transferase I
    Ia- Acyl-CoA + carnitine--> Acly-Carnitine + CoA (in intermembrane space of mtch)

    Ib- same reaction as above but occurs in cytosol
  2. Carnitine shuttle
    - NOT required for short and medium chain FA (</= 12 C)
  3. phosphatidate
    • - very important though made in small amounts
    • - precursor to phospholipids
    • - phosphotidate + CTP --> CDP-diglyceride
  4. phospholipase D
    - removes head groups from phospholipids
  5. DPPC:S ratio
    • - used to determine maturity of lungs in premature babies
    • - DPPC:S = 2:1= lungs mature

    - DPPC:S < 2= increased S or decrease DPPC= premature lungs
  6. phospholipase A1
    - removes FA from C1 of a phospholipid
  7. phospholipase A2
    • - removes FA from C2 of a phospholipid
    • - inhibited by glucocorticoids
    • - releases arichidonic acid for prostaglandin and thromboxane synthesis
  8. phospholipase C
    - remove head group and high E phosphate from phospholipid
  9. sphingomyelin
    - complex lipid of myelin sheaths
  10. glycosphingolipids
    • - act as antigenic determinants of the ABO blood groups
    • - NAG- A
    • - galactose- B
  11. Sandoff Disease
    • - rare AR hexosaminidase A and B deficiency
    • - looks just like Tay Sachs
    • - Cherry red macula
  12. salivary enzymes
    - alpha amylase- breaks alpha-1,4 glycosidic bonds

    • - lysozyme- endoglycosidase, cleaves beta-1,4 glycosidic bonds=> kills most Gram + bacteria
    • - lingual lipase
  13. trypsinogen
    • - zymogen(inactive precursor)
    • - converted to active form "trypsin", by pancreatic enteropeptidase
    • - once activated, trypsin can activate all other pancreatic enzymes, including other trypsinogens
  14. oriental flush
    • - aldehyde dehydrogenase variant
    • - leads to EtOH accumulation in blood=> S/S, sickness and flush
  15. ketogenic AA
    • - leu and lys
    • - produce Ac-CoA
  16. enzymes released after minor hepatocyte damage
    • - ALT
    • - GPT
  17. simplest AA to turn into glucose precursors
    - Ala and Ser
  18. AST and GOT
    • - unspecific markers of cells damage in heart, SkM or liver
    • - involved in conversion of Glu, Glun, Asp and Asn
  19. ALL
    • - acute lymphoblastic leukemia
    • - blasts have low Asn synthetase and can be starved of blood Asn by injection of Asparaginase
  20. B12 requiring reactions
    - methionine synthase

    - methylmalonyl CoA mutase

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