MedChem Exam 2

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ffloyd
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138740
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MedChem Exam 2
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2012-03-01 13:43:31
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MedChem Exam ffloyd drug interactions statins vitamins natural products carboydrates
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MedChem Exam 2 ffloyd drug interactions statins vitamins natural products carboydrates
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  1. cyclosporine uses CYP____ and interacts with ______statin
    CYP3A4 ; LOVAstatin
  2. Erythromycin is an inhibitor of CYP___ . Good alternatives would be _______________ or _____________
    CYP3A4 ; clarithromycin or troleandomycin
  3. Azole antifungals are potent ________ of CYP3A4. But fluconazole uses the CYP_____ pathway.
    inhibitor ; CYP2C9
  4. ___________ and statins have a an additive effect on myopathy and rhabdomyolysis
    gemfibrozil
  5. Nefazodone(Serzone) strongly inhibits _________. Name 2 statins it would not interfere with.
    CYP3A4 ; pravastatin or fluvastatin
  6. Verapamil(Calan) is a _____________ of CYP3A4
    inhibitor
  7. Drug type for morphine
    narcotic analgesic
  8. Drug type for quinine
    antimalarial
  9. Drug type for quinidine
    antiarrhythmic
  10. Drug type for vinblastine
    anticancer
  11. Drug type for atropine
    anticholinergic
  12. Drug type for paclitaxel (Taxol)
    anticancer
  13. Drug type for etoposide
    anticancer
  14. in the Mevalonic pathway:
    3 acetic acid => _________
    HMG
  15. in the Mevalonic pathway:
    HMG =(HMG-CoA reductase)=> _________
    mevalonic acid
  16. What is the rate limiting step in the Mevalonic pathway?
    HMG-CoA reductase (can be inhibited by statins)
  17. the 10C isoprene unit is _____
    geranyl
  18. the 15C isoprene unit is ______
    farnesyl
  19. the 30C isoprene unit is _______
    squalene
  20. the isoprene unit squalene can be converted in to ________
    cholesterol
  21. Name 3 significant terpenes from the notes:
    • 10C - menthol
    • 10C - camphor
    • 40C - beta carotene
  22. what is the phenylpropanoid that is the basis of all amino acids and benzene rings in plants?
    shikimic acid
  23. flavonoids can serve as what?
    antioxidants and possible inhibitors of p-glycoprotein pumps
  24. what common drug is derived from shikimic acid?
    warfarin
  25. a catechol is a benzene with hydroxides in what position?
    1 and 2
  26. what two natural product metabolites are derived from shikimic acid?
    lignans and tannins
  27. tetracyclines are derived from what natural product metabolite?
    polyketides
  28. digoxin is derived from what natural product metabolite?
    glycosides
  29. nitrogen containing ring stuctures are indicative of what natural product metabolite?
    alkaloids
  30. nicotine, cocaine, caffeine, strychnine, quinine, and morphine are all derivatives of what natural product metabolite?
    alkaloids
  31. glucose, sucrose, starch, and glucoronic acids are all important what?
    carbs
  32. name 3 important high molecular weight polysaccharides from the notes:
    • sodium heparin
    • hyaluronic acid
    • glycogen
  33. T/F: all plasma proteins are glycosylated?
    F - NOT ALBUMIN
  34. glycosylation patterns have been shown to influence what?
    molecular targeting and cell-to-cell recognition
  35. sorbitol and mannitol are both what?
    medicinally useful sugar alcohols
  36. what are 2 differences btw mannitol and sorbitol?
    • mannitol - nonhygroscopic; osmotic diuretic
    • sorbitol - hygroscopic ; sweetener
  37. Glucurone (D-glucuronic acid) can be used to treat what?
    arthritis
  38. what 2 carbs are used as fluid and nutrient replenishers?
    dextrose and fructose
  39. what 2 carbs are used extensively in infant and adult invalid formulas?
    maltose and dextrins
  40. what carb can be used to detect celiac disease?
    xylose
  41. what kind of carb is heparin?
    mucopolysaccharide
  42. what type of charge does heparin carry?
    highly negative charge
  43. Statins may to a deficiency in what provitamin?
    provitamin D3
  44. what is required for VitD GI absorption?
    bile
  45. what is unique about the topical VitD analog calcipotriene(Dovonex)?
    it has 100-200 times less effect on calcium metabolism
  46. what 2 roles does VitE play?
    scavenges lipid peroxides and protein synthesis
  47. absorption of what B vitamin is sodium dependent?
    B1
  48. what B vitamin is provided in the form of CoEnzyme A?
    B5
  49. what form of niacin is NOT antilipidemic?
    niacinamide
  50. Niacin deficiency can lead to what?
    pellagra and the 3 D's (diarrhea, dermatitis, dementia)
  51. Riboflavin has drug interactions with what 3 things?
    phenothiazines, probenecid, and TCAs
  52. what are riboflavin solutions susceptable to?
    light deterioration
  53. what vitB can help with PMS and migraines
    B6
  54. what are 3 signs of B6 defieciency?
    skin disorders, neuropathy, convulsive seizures
  55. B6 has drug interactions with what 4 things?
    hydrazines, OCs, cycloserine, levodopa
  56. What is B12 absorption dependent on?
    intrinsic factor
  57. what is folic acid needed for?
    purine sythesis by 1C methyl transfer
  58. what is Leucovorin rescue?
    counteracts folic acid overdose
  59. what drug inhibits 1C methylation?
    methotrexate

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