Card Set Information
Functions of blood (transport)
*gas transport*O2 and CO2
nutrients from food
,enzymes,waste products hormones
functions of blood (regulation)
functions of blood (protection)
blood loss,immune system-protects against pathogens(disease causing organisms)
under what circumstances would you collect blood from an artery using an arterial stick which is the common artery
(common to do radial using arterial stick) 02 content measure
what are the advantages to collect blood from a vein
1) easy to locate 2)lower pressure(seal sooner) 3)have thinner wall(easier to puncture)
characteristics of blood (volume) and (ph)
females 4-5L males 5-6L
chartacteristics of blood (body weight)(viscosity) (temp)
8% of body weight is blood
5-8 times more viscous than water
temp 38degreesC 100.4 F*blood is warmer than body*
blood chartacteristics (hypovolemic) (hypervolemic)
hypovolemic:lowblood vol.(bleeding dehydration)
hypervolemic(due to over hydration and some blood disorders) *hyper less common*
portion of blood composed of plasma
55% of blood volume is plasma
how much plasma is water
91.5 percent is water is plasma
what solutes would be found suspened in plasma?
electrolyts=ions,nutrients,02 and co2,hormones,enzymes,metabolic wastes
what does fibrinogen do?
what plasma protein is part of the immune system?
immunogolbins IgG IgA IgE IgD IgM spells GAMED
what plasma protein controls most of the exchange?
Albumins controls most of the exchange in the capillary
Albumins carry what?
fatty acids and steroid hormones
Albumins are found in and determine most of what?
found in egg whites and determine most of BCOP
WHAT WILL BE TRANSPORTED BY GLOBULINS
metalioproteins-transport metal ions
what portion of blood is composed of formed elements
45percent is composed of formed elements
how many erythrocytes are in a microliter of blood
4.8-5.4 million are in microliter of blood
what r the percentages of the wbc's?
what is a hemocytoblast?
blood cell stem cell can differntiate into any blood cell
what does colony forming units play in the development of formed elements?
act as signaling molecule to direct differemtiation
what precurser cells will give rise to elements?(megakaryoblast)
megakaryocytes breaks up into thromocytes aka platelets
what precurser cells will give rise to elements?(proerythroblast)
mature into erythrocytes
what precurser cells will give rise to elements? MYELOBLAST
eosinophil, neutrophiler, basophil
what precurser cells will give rise to elements? MONOBLAST
monocytes aka macrophage
what precurser cells will give rise to elements? LYPHOBLAST
how is an agranulocte different from a granulocyte?
agranulocyte have no visual in cytoplasm
granulocytes have visual in cytoplasm
eosinophil basophils neutrolphil
monocytes and lymphocytes
emigration process by which WBC leaves blood and moves into interstitial fluid
how chemotaxis affect leukocytes
chemical attraction to wbc
on endotheial cell act as an adhesian molecule to grab on wbc
on WBC use them to tether to the endotheial cell and roll down surface
how does the lack of nucleus affect erythrocytes?
no dna no mitosis,dont make proteins,little no cell repair,no mitrochondria,use glycolysis to make atp (2 atp/glucose) *no mitro cause it would use all 02 to make energy*
why the shape of rbc is important
donut biconcave disc
1allows to stack on top
2narrow area in the middle allows them to fold twist and bend 2 get thru small vessels
3high surface area to volume ratio
how many molecules of hemoglobin will each erythrocyte contain?
250-280million hemoglobin molecules
how many oxygen can a single hemoglobin bind?
4 oxygen molecules hemoglobin carries
which component of hemoglobin is composed of protein
globin units is composed of protein
which component of hemoglobin will give blood its color?
heme gives blood its color
what metal ion is within hemoglobin?
what gases bound to what components of hemoglobin
heme o2 globin co2
types of conditions decrease in blood oxygen concentration
hypoxia,blood loss, anemia, increased elevation
which hormones will increase the production of rbc's
how does erythropoeitin act
receptors in kidneys detect low O2->erythropoeitin released->1incresed production of proerythroblasts 2increased rate of maturity
how long do erythrocytes live
120days erythrocytes live
where in the body are erythrocytes broken down?
macrophage in spleen liver or bone marrow
what does globin break down into?
what role does transferrin play during the break down of erythrocytes
takes heme-> transferrin + fe3 = ferritin
what is biliverdin