MCMP 408 Midterm

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MCMP 408 Midterm
2012-03-02 08:30:50
MCMP 408 Midterm

difficult midterm material
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  1. Ergot Alkaloid DDIs
    • beta-blockers, macrolides, HIV protease inhibitors
    • *DHE decreases efficacy of nitrates
  2. Sumatriptin DDI, CI
    MAO inhibitors (increases bioavailability), CI with CAD cause can precipitate angina
  3. Zolmitriptan SE, CI
    Wolff-Parkinson-White syndrome- arrhythmia, CI with CAD cause can precipitate angina
  4. Naratriptan CI
    severe hepatic or renal impairment, peripheral vascular disease, CAD cause can precipitate angina
  5. Rizatriptan CI
    phenylketonuric syndrome- cause it contains phenylalanine, CAD cause can precipitate angina
  6. Polymorphisms of this CYP isoform can alter the
    pharmacokinetics of nortriptyline
  7. the voltage sensor of voltage-gated ion channels
    (like KvAP) is
    A high density of positively charged amino acids- under norm circumstances, neg inward potential pulls on VS and maintains closed conformation of channel. When depolarization occurs, the potential becomes more pos, repelling the VS and causing channel opening and allowing ion flow.
  8. Thiazide diuretic AEs
    hyperuricemia, k wasting, hyperglycemia, hypokalemic metabolic alkalosis, impaired carb tolerance, hyperlipidemia, hyponatremia
  9. Clonidine
    alpha-2 agonist
  10. Captopril
    Sulfhydryl-containing ACE inhibitor
  11. Captopril unique SE
    metallic taste, skin rash (due to sulfhydryl group)
  12. loop diuretics
    furosemide, bumetanide, ethacrynic acid
  13. loop diuretic indications
    edema, acute pulmonary educa, acute hypercalcemia, hyperkalemia, acute renal failure, anion OD
  14. loop diuretic SE
    K wasting, dehydration, hyopkalemic metabolic alkalosis, ototoxicity, hyperuricemia, hypomagnesemia
  15. thiazide diuretics
    anything ending with "thiazide," and metolazone, indapamide, chlorthalidone
  16. Thiazide indications
    HTN, CHF, nephrolithiasis due to idiopathic hypercalciuria, nephrogenic diabetes insipidus
  17. K sparing diuretics
    • Na channel blockers: triamterene, amiloride
    • Aldosterone/mineralocorticoid antagonists: spironolactone, eplerenone
  18. Demeclocycline
    ADH antagonist
  19. direct vasodilators
    hydralazine, minoxidil, sodium nitroprusside "nitrates"
  20. ACE inhibitor DDIs
    • Antacids, NSAIDS, K supplements/K-sparing diuretics
    • ACEis increase bioavialability of digoxin and lithium