Pharm Chapter 13.txt

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139606
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Pharm Chapter 13.txt
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2012-03-04 18:16:23
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Pharm Chapt 13
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Pharm Chapt 13
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  1. AIDS is caused by
    a retrovirus named HIV
  2. Retroviruses are viruses that contain
    RNA instead of DNA
  3. What HIV enzyme is responsible for creating proviral DNA from viral RNA?
    Reverse transcriptase
  4. Antiretrovirals
    slow growth or prevent duplication of retroviruses
  5. Valtrex is used for
    genital herpes
  6. Acyclovir is used for
    Varicella zoster
  7. Two types of antiretrovirals
    reverse transcriptase inhibitors (early stages of virus) and protease inhibitors (later in lifecycle of virus)
  8. Reverse transcriptase inhibitors prevent
    HIV enzyme reverse transcriptase from creating HIV proviral DNA from the viral RNA
  9. Two categories of reverse transcriptase inhibitors
    nucleoside analogue RTI and nonnucleoside analogue RTI
  10. Protein inhibitors
    block the HIV enzyme protease and prevent them from being cleaved
  11. Most antiretroviral agents inhibit cytochrome P450 enzyme system involved in metabolizing meds through the liver. (should be shaken before use)
  12. Patients taking indinavir sulfate may develop Crix Belly, which is
    elevated triglycerides, cholesterol and plasma glucose with 40 lb weight gain with fat in abdomen and lost in arms and legs
  13. Superficial infection
    in skin or nail
  14. Systemic infection
    lung or liver
  15. Type of antifungal
    nystatin, diflucan
  16. Antifungals interfere with alcohol severely
  17. The absorption rate of griseofulvin is increased after
    patient eats a fatty meal
  18. Ketoconazole requires
    stomach acidity
  19. Retroviruses are
    messenger RNA that codes for HIV polyprotein
  20. Mycotic infection refers to infection caused by
    yeast
  21. Fungi are found in lungs and skin/nailbeds
  22. Adverse drug reactions produced by antifungals are
    associated with hepatotoxicity
  23. Superinfections may result with prolonged use of antifungals concurrently with
    corticosteroids
  24. Antifungal medications have which of the following actions
    Allow intracellular components to leak through the cell membrane, increase cell membrane permeability, inhibit nucleic acid synthesis

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