Dopamine

Card Set Information

Author:
Kgren
ID:
139762
Filename:
Dopamine
Updated:
2012-03-05 09:14:34
Tags:
Paramedic Drugs
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Description:
Dopamine
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  1. Class
    Sympathetic Agonist
  2. Description
    Naturally occurring Catecholamine. Chemical precursor of NE. Acts on A and B1 dopaminergic receptors. Adrenergic receptors are dose dependent
  3. Mechanism of Action
    • Increases BP acting on Alpha and Beta1 adrenergic receptors.
    • Increases systolic and pulse pressure
    • Beta1-positive inotropic effects on heart w/out increased myocardial O2 demand and powerful effects of drugs like Epi.
    • Alpha- Adrenergic receptors causing vasoconstriction
  4. Onset of Action
    • Onset: <5min
    • Peak: 5-8min
    • Duration: <10min
    • Half-life: 2min
  5. Indications
    • Hemodynamically significant hypotension NOT from hypovolemia.
    • Cardiogenic shock
    • Symptomatic bradycardia refractory to Atropine
    • Neurogenic shock
    • Distributive shock
  6. Contraindications
    • Hypovolemic shock where complete fluid resuscitation has NOT occurred.
    • Pheochromocytoma
  7. Precautions
    • Severe tachydysrhythmias or V-Fib
    • May worsen/induce SVT & ventricular arrhythmias
    • Benefits lost in doses over 20ug/kg/min
    • Deactivated by Sodium Bicarb
    • Reduce dose if on MAOI's
    • Hypotension if on Dilantin
  8. Side Effects
    • Palpitations
    • Nervousness
    • Headache
    • Chest pain
    • Dyspnea
    • Nausea
    • Vomiting
    • Arrhythmia
    • HTN
    • Tachycardia
  9. Adult Dose
    • Renal: 1-2ug/kg/min to perfuse kidneys
    • Cardiac: 2-10ug/kg/min symptomatic bradycardia refractory to Atropine, pacing, cardiogenic shock
    • Vascular: 10-20ug/kg/min neurogenic shock, distributive shock. 2nd line for anaphylaxis and sepsis
  10. Pedi Dose
    2-20ug/kg/min
  11. Max Dose
    20ug/kg/min
  12. Route of Administration
    IV drip only
  13. How Supplied
    400mg vials, 800mg vials, prefilled bags

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