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Naturally occurring Catecholamine. Chemical precursor of NE. Acts on A and B1 dopaminergic receptors. Adrenergic receptors are dose dependent
Mechanism of Action
- Increases BP acting on Alpha and Beta1 adrenergic receptors.
- Increases systolic and pulse pressure
- Beta1-positive inotropic effects on heart w/out increased myocardial O2 demand and powerful effects of drugs like Epi.
- Alpha- Adrenergic receptors causing vasoconstriction
Onset of Action
- Onset: <5min
- Peak: 5-8min
- Duration: <10min
- Half-life: 2min
- Hemodynamically significant hypotension NOT from hypovolemia.
- Cardiogenic shock
- Symptomatic bradycardia refractory to Atropine
- Neurogenic shock
- Distributive shock
- Hypovolemic shock where complete fluid resuscitation has NOT occurred.
- Severe tachydysrhythmias or V-Fib
- May worsen/induce SVT & ventricular arrhythmias
- Benefits lost in doses over 20ug/kg/min
- Deactivated by Sodium Bicarb
- Reduce dose if on MAOI's
- Hypotension if on Dilantin
- Chest pain
- Renal: 1-2ug/kg/min to perfuse kidneys
- Cardiac: 2-10ug/kg/min symptomatic bradycardia refractory to Atropine, pacing, cardiogenic shock
- Vascular: 10-20ug/kg/min neurogenic shock, distributive shock. 2nd line for anaphylaxis and sepsis
Route of Administration
IV drip only
400mg vials, 800mg vials, prefilled bags