11,000 deaths (low) in U.S. annually (7th most common cause of death from cancer)
Extremly high in Japan and China
75% of patients, age > 50 yrs
Blood tests including CBC should be done to assess anemia
CEA should be measured before and after surgery
What are the common causes of Stomach Cancer?
1. H. pylori
2. Autoimmune atrophic gastritis and various genetic factors
3. Gastric polyps - precursors to cancer
4. Chronic gastritis leading to ulcers
An extremely common form of cancer. Symptoms include blood in stool or change in bowel habits
Screenings for fecal occult blood (FOB) are done (annually after age 50 yrs).
Diagnosis through colonoscopy (instead of sigmoidoscop)
153,000 cases and 52,000 deaths annually
New cases on the rise but still not beating Lung Cancer rise
Excessive accumulation of lipid in hepatocytes. The most common response of the liver to injury. The most common cause of macrovascular type of this condition
Pathogenesis: triglycerides accumulate in the liver because of increased input through synthesis from FFA (free fatty acids) or decreased export as VLDL from the hepatocytes. Increased triglyceride synthesis may result from increased delivery or availability of FFA or from decreased oxidation of FFA in the liver
Pathology: Triglycerides accumulate as large droplets displacing nuclei making cells look "fat"
Decrease in the number of RBC's and Hb (hemoglobin) content caused by blood loss, deficient erythropoiesis (RBC production), excessive hemolysis (RBC destruction), or any combination of the above.