Antitubercular Agents-End

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Author:
Anonymous
ID:
14087
Filename:
Antitubercular Agents-End
Updated:
2010-04-12 14:57:40
Tags:
Medchem
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Description:
medchem
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  1. Tuberculosis
    • slow growth
    • long treatment time (6-9 months)
  2. First Line Anti-Tuberculosis drugs
  3. Isoniazid
    • ethambutol
    • rifampin
    • Pyrazinamide (cidal)
  4. Second-Line Tuberculosis Agents
    • cycloserine
    • Kanamycin
    • capreomycin
    • ethionamide
    • p-aminosalicylic acid
  5. Isoniazid***
    • Ethambutol
    • Only active against dividing mycobacteria
    • Pyrazinamide
    • short term therapy
    • hepatotoxicity
    • used only in combination therapy
    • P-Aminosalicylic Acid
    • increases the level of free isoniazid
  6. Rifamycins
    • active against G+ and M. Tuberculosis
    • Some G- and viruses
    • Inhibitors of DNA directed RNA polymerase
    • Bacteriocidal
    • Rifampin
    • most active agent for treatment of Tuberculosis
    • Used only in combo
    • Inducer of hepatic P450 Oxygenases
    • Increases effects of aids medications
    • Cycloserine
    • prevents synthesis of cross-linking peptide in formation of bacterial cell walls
  7. Anthelmintics
    drugs that have the capability to rid the body of parasitic worms or helminths
  8. Piperazine***
    • Neurotoxic Anti-Helmintics
    • Thiabendazole
    • Inhibits fumarate reductase
  9. Mebendazole
    blocks glucose uptake
  10. Ivermectin
    treatment of "river blindness"
  11. Benzylbenzoate***
    • Lice treatment

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