Lipid drugs.txt

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cdubb777
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141035
Filename:
Lipid drugs.txt
Updated:
2012-03-11 19:33:44
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lipid drugs
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lipid drugs
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  1. Which is the strongest statin?
    Rosuvastatin (Crestor.)
  2. What's the brand name of Simvastatin?
    Zocor.
  3. What's the brand name of Atorvastatin?
    Lipitor.
  4. What's the brand name of Pravastatin?
    Pravachol.
  5. What's the brand name of Lovastatin?
    Mevacor, Altoprev.
  6. What's the brand name of Fluvastatin?
    Lescol.
  7. Statins are best for lowering which lipid marker?
    LDL (by 18-55%)
  8. Which class of drugs raises HDL the most (by 15-35%)?
    Nictoinic acid.
  9. Which 2 classes are used to lower TG (by 20-50%)
    Nicotinic acid and Fibric acids.
  10. Name 2 fibric acids.
    Gemfibrozil, Fenofibrate
  11. What are the top 2 side effects of statins?
    Myopathy, increased liver enzymes.
  12. What is a top side effect of bile acid sequestrants?
    GI distress (nausea/constipation)
  13. What is a 3 side effects of nicotinic acid?
    • Flushing, hyperglycemia, hyperuricemia
    • (also hepatotoxicity)
  14. What is a 3 side effects of fibric acids?
    Dyspepsia, gallstones, myopathy.
  15. Which 2 classes of lipid drugs have possible side effect of myopathy?
    Statins, fibric acids.
  16. Which 2 classes of lipid drugs have possible side effect of hepatotoxicity?
    Statins, nicotinic acids.
  17. Which class of lipid drugs have possible side effect of gallstones?
    Fibric acids
  18. Which class of lipid drugs is contraindicated in severe gout?
    Nicotinic acids
  19. What's the brand name of Gemfibrozil?
    Lopid.
  20. Which class is Trilipix in? What's the generic name?
    • Class: Fibric acids.
    • Name: Fenofibric acid.
  21. Which 2 drugs does Vytorin combine?
    Ezetimibe and simvastatin.
  22. What's the brand name of Ezetimibe?
    Zetia.
  23. Which drug blocks absorption of cholesterol in the gut?
    Ezetimibe (Zetia)
  24. Which drug combines a Cholesterol absorption inhibitor with a statin?
    Vytorin.
  25. Which drug is a combo of Zetia/Zocor?
    Vytorin.
  26. What is the brand name of Pitavastatin?
    Livalo.
  27. What's the name for Welchol?
    Colesevelam.
  28. What class of drug is Welchol?
    Bile acid sequestrant.
  29. What are 3 bile acid sequestrants?
    Cholestyramine, Colestipol, Colesevelam.
  30. Which is the only fibrate approved to be used with statins?
    Trilipix.
  31. Name the top 3 strongest statins by generic name.
    Rosuvastatin, Atorvastatin, Simvastatin
  32. Name the top 3 strongest statins by brand name.
    Crestor, Lipitor, Zocor
  33. What time of day are statins usually taken? Why?
    At night, because liver makes more cholesterol at night.
  34. Which statin is best taken with food?
    Lovastatin (Mevacor)
  35. What is the cholesterol/HTN combo drug?
    Caduet (amlodipine/atorvastatin).
  36. What's Simcor a combination of?
    Niaspan and Simvastatin.
  37. What class of HTN drug and lipid drug does Caduet
    have?
    CCB and statin.
  38. Which class can actually increase triglycerides?
    Bile acid sequestrants
  39. What is Tricor?
    Fenofibrate.
  40. When should you check LFTs after starting a statin? What levels would be indication to stop?
    1st baseline, and Monitor 12 weeks after starting. D/C if LFTs are> 3x upper limit of normal.
  41. What class of meds have been reported to increase risk of DM?
    Statins (possobly by increasing insulin resistance in tissues.
  42. Which 3 Statins are CYP3A4 metabolized?
    • Lipitor, Mevacor, Zocor but least with Lipitor
    • ALS (atorv, lova, simva)
  43. What drugs do you have to be careful with those statins that are CYP3A4 metabolized because of increased myopathy/ rhabdo risk? (5x higher for strong inhibitors)
    Amiodarone, azole antifungals, CCBs, cyclosporine, fibric acids, grapefruit juice, niacin, nefazodone, protease irnhibitors, macrolides
  44. What heart drugs do you have to be careful with those statins that are CYP3A4 metabolized because of increased blood levels
    Digoxin (20% higher)
  45. Which other cholesterol drug lowers bioavailability of statins?
    Bile acid sequestrants
  46. Which statins are not really metabolized by the p450 system?
    Rosuvastatin, pitavastatin, pravastatin
  47. Which Statin is CYP2C9 metabolized?
    Fluvastatin (Lescol)
  48. Which macropods least likely to interact with statins?
    Azithromycin
  49. What are drugs that increase triglycerides?
    Oral estrogens, atypical antipsychotics, beta-blockers, thiazides, protease imhibitors
  50. When initiate drug therapy for TG?
    When > 200 w/ high LDL or over 500 , esp w/ Hx of pancreatitis (focus on diet + wt loss initially)

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