Card Set Information
What kind of bacteria is C diff?
spore forming gram (+) anaerobic bacillus
Which 2 classes of antbx are most assoc w/ C. diff?
clindamycin and fluroquinolones
What are risk factors?
age >65 y/o, IBD, immunocompromised, PPIs, recent GI surgery, ileus, antiperistaltic meds, stay in ICU/long term care
Can you kill the spores?
resistant to high heat, ETOH hand sanitizers, UV light, and cleaning chemicals
What are usual initial sx?
watery diarrea, nausea, fever, lower abd pain/cramping. +/- mucus in stool, usually no blood
How to dx?
gold std: cell culture cytotoxic assay. Other: enzyme immunoassay, PCR
how to treat initial episode for mild-moderate?
Metronidazole 500 mg PO TID 10-14 days
how to treat initial episode for severe?
Vancomycin 125 mg QID PO 10-14 d. If hypotension/shock/megacolon, both!
How to treat a 1st recurrence? 2nd?
: same as initial episode
How is C diff usually transferred from person to person?
fecal-oral or thru fomites
What are S&S of fulminant/pseudomembranous colitis?
high volume, foul smelling diarrhea (15-30 qd), may be bloody,leukocytosis, fever, hypoalbuminenmia, hypotension, rising Creatinine
Which drug for tx is associated w/ neurotoxicity and hence shouldn't be used for recurrent recurrences?