- Peak age at onset between 20 and 30
- Women affected 3X more often than men
- Chronic, sporadic, progressive
- -weakness, fatigue
- -has remissions and exacerbations
Occurs when the immune system makes antibodies that damage or block many of the muscles ACh receptors on the surface of muscle cells. This prohibits ACh from binding to the damaged receptors and acting on the muscle, which reduces muscle contractions, leading to weakness and fatigue.
Caused by a defect in the transmission of nerve impulses to muscles.
because the immune system which normally protects the body from foreign organisms, mistakenly attacks itself.
Onset is usually slow although some instances of fairly rapid development may be caused by infection, emotional upset, pregnancy or anesthesia.
Some patients have thymoma- most of the remaining cases show hyperplasia of the thymus.