compounding theory

Card Set Information

Author:
cdsack
ID:
141769
Filename:
compounding theory
Updated:
2012-03-15 13:30:16
Tags:
suppositories
Folders:

Description:
study notes
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user cdsack on FreezingBlue Flashcards. What would you like to do?


  1. routes of administration
    • vaginal
    • rectal
    • urethral
  2. dosage forms
    • suppositories
    • solutions
    • ointments
  3. rectal route - advantages:
    • patients who suffer from extream nausea and vomitting
    • unconsious patients
    • pediatrics
    • no taste limitations
    • hepatic (liver) bypass
    • gastric (stomach) bypass
  4. rectal route - disadvantages
    • absorption interrupted by pooping
    • small surface area
    • inconvenient
    • absorption can be erratic and unpredictable
    • "leakage" or expelled after insertion
  5. shapes and sizes (rectal)
    • torpedo (pointed end tapered to blunt end)
    • adult: 20mm, 2g
    • child: 10mm, 1g
    • max amound of solid materal is 30% of blank weight
    • **no more than 500mg can be incorporated into rectal suppositories
  6. rectal suppositories effects
    • local: treats hemmoroids, inflammation
    • systemic: treats fever, pain, infection

    *drugs are absorbed via passive diffusion
  7. factors that affect absorption of rectal supp.
    • site
    • absorption enhancer used
    • colonic content
    • suppository base used
  8. vaginal supp. advantages
    • less toxic (less absorption than oral)
    • dose can be retrieved
    • long term administration (IUDs)
    • improved compliance
  9. vaginal supp. disadvantages
    • absorption can be variable (depending on viability of vaginal walls)
    • toxic shock
    • can be expelled
  10. vaginal formulations
    • solutions
    • powders for solutions
    • ointments, creams
    • aerosol foams
    • supp. (globule, oval shaped, blank weigh 3-5g)
  11. vaginal formulation uses
    • contraceptives
    • feminin hygeine antiseptic
    • bacterial antibiotic
    • restore vaginal mucosa
  12. urethral administration
    • not very common
    • inserted into urethral
  13. urethral uses
    • antibacterial
    • local preparative anesthetics
    • erectile disfunction
  14. suppository bases: ideal materials
    • non-toxic
    • non-irritating
    • inert
    • compatible
    • easily pilable into desired shape
  15. suppository base classes
    • 1: oleaginous (fatty)
    • 2: water soluble or miscible
  16. types of oleaginous bases
    • 1: theobroma oil (cocoa butter)
    • 2: synthetic triglyceride mixtures
  17. theobroma oil (cocoa butter)
    *base not heated over 35oC *adding phenol lowers melting point*adding beeswax raises melting point
  18. synthetic triglyceride mixtures
    • not same formulation of cocoa butter
    • doesnt exhibit polymorphism, *contolling temp. not important
    • Ex: Wecobee, MBK, FattiBase
  19. types of water soluble/miscible bases
    • glycerinated gelatin
    • polythylene glycol (PEG) polymer
  20. glycerinated gelatin
    • add preservatives: methylparaben
    • supp dipped in water before use
    • translucent, resilent, gelatinous
    • provide prolonged release of A.I.
    • store in sealed containers, will absorb and dissolve in atmospheric moisture
  21. polyethylene glycol (PEG) polymer
    • chemically stable, nonirrating, miscible in water and mucous secretions
    • can be formulated by molding or compression in wide range of hardness and melting points
    • do not melt at body temp.
    • dissolve to provide more prolonged release than cocoa butter
  22. methods of prep
    • hand rolling: cocoa butter base
    • compression: forced into special compress
    • fusion: melt, disperse drug into melted base, pour into mold
  23. instability of suppositories
    • excessive softening
    • hardness
    • dried out
    • oil staining on packaging
  24. storage
    • protect from heat
    • refrigerate (do not freeze)
    • glycerin and PEG kept in tight sealed container

What would you like to do?

Home > Flashcards > Print Preview