-
ACE Inhibitors
- -pril ending
- Captopril
- Enalapril
- HTN, CHF (dec mortality)
- bad: cough(bradykinin), hyperkalemia
- bradykinin(vasodialator) usually broken down by ACE
-
AT-Receptor antagonists
- -SARTAN
- Losartan
- AT1 receptor inhibitor
- no "bradykinin" effects
-
Renin Inhibitors
aliskirin
-
Sites of action of drugs that relax vascular smooth muscle
-
Gingival hyperplasia:
- nifedipine (Ca2+ channel blocker)
- cyclosporin (immune suppressant, transplants)
-
HTN implications for dentistry
- Care in use of vasoconstrictors
- (e.g. supersensitivity to catecholamines with guanethidine)
- Orthostatic hypotention
- (common to all antihypertensive drugs)
- Judicious use of CNS depressants
- (esp. with centrally-acting antihypertensive drugs)
- Salivary inhibition
- (xerostomia common with centrally-acting antihypertensive drugs)
- NSAIDs
- (decrease action of captopril, spironolactone, furosemide)
- Gingival hyperplasia
- (with long-term use of Ca2+channel blockers)
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