Liver disease

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  1. In which abdominopelvic quadrant is the pancreas located?
  2. Which vein brings blood full of nutrients from the digestive tract to the liver, before it enters the systemic circulation?
    hepatic portal vein
  3. which organ can regenerate itself?
  4. which organ secretes the enzyme trypsin?
  5. these organs secrete digestive enzymes, with the exception of
    A. salivary glands
    B. small bowel
    C. stomach
    D. liver
    E. pancreas
    D. liver
    (this multiple choice question has been scrambled)
  6. what organ secretes bile acids?
    c. liver
  7. Describe the composition of pancreatic juice
    water, bicarbonate and digestive enzymes
  8. What hormones secreted by the pancreas are involved in blood glucose regulation?
    insulin and glucagon
  9. Which endocrine gastrointestinal regulatory peptide stimulates gallbladder contraction and pancreatic secretions in response to peptides, amino acids, and fatty acids in the duodenum and jejunum?
  10. which endocrine gastrointestinal regulatory peptide stimulates biliary and pancreatic bicarbonate secretion in response to acid in the duodenum?
  11. what are liver cells called?
  12. Which autosomal recessive congenital metabolic disorder is characterized by progressive decline of lung and pancreas function due to abnormal exocrine body secretions plugging up passageways, such as bronchi, pancreatic and bile ducts, and intestines?
    cystic fibrosis
  13. hepatomegaly
    enlargement of the liver
  14. hepatitis
    an acute or chronic inflammation of the liver due to liver cell injury
  15. liver steatosis
    fatty liver or abnormal and excessive accumulation of fat in hepatocytes causing degeneration and enlargement of the liver tissue
  16. cirrhosis
    a chronic and irreversible cellular destruction of the liver with scarring and fibrosis causing nodular architecture distortion, loss of cell function, and signs and symptoms of liver failure, including jaundice, portal hypertension, and ascites
  17. bilirubin
    a reddish yellow pigment formed during the catabolism of hemoglobin from red blood cells, and is excreted in bile.
  18. jaundice
    a yellowish coloration of the skin and body tissues due to abnormally elevated concentrations of bilirubin in blood and tissues
  19. encephalopathy
    a disorder producing alteration of brain structure and degeneration of mental function
  20. wernicke's encephalopathy
    an inflammation of the brain with hemmorrhage due to thiamin deficiency produces alteration of brain structure and degeneration of mental function, especially seen in severe alcoholism
  21. lithiasis
    the production of calculi or stony concretions in the body
  22. cholelithiasis
    the presence of cholesterol stone(s) in the gallbladder or bile duct
  23. cholecyst
    a synonym for gallbladder
  24. gallstone
    a lithiasis in the gallbladder or a bile duct
  25. cholelith
    a synonym for gallstone
  26. cholecystolithiasis
    a condition characterized by the presence of gallstone(s) in the gallbladder
  27. cholestasis
    a condition of bile flow arrest or failure
  28. cholecystitis
    an inflammation of the gallbladder
  29. cholecystectomy
    the removal of the gallbladder
  30. hemochromatosis
    an inherited disorder of iron metabolism causing excess iron absorption and deposition in tissues and organs, including the skin, joints, pancreas, liver, and heart
  31. pancreatitis
    an inflammation of the pancreas due to cell damage
  32. pancreatectomy
    a removal of part or all of the pancreatic tissue by surgery
  33. What may trigger the formation of gallstones?
    • -bile supersaturation with cholesterol
    • - stasis (lack of contraction) of the gallbladder
  34. What factors and disease conditions are associated with an increased risk for the formation of cholelithiasis?
    • -increasing age
    • -femal sex
    • -estrogens
    • -pregnancy
    • -diabetes
    • -obesity
    • -prolonged fasting
    • -cystic fibrosis
    • -rapid weight loss
    • -total parenteral nutrition
  35. What factors are commonly involved in the pathogenesis of hepatitis?
    • -viral infection
    • -toxic agents: alcohol, drugs, etc.
    • - alcoholism
    • -hemochromatosis
    • -ischemia
  36. What is the most frequent etiology for chronic liver disease?
  37. What are clinical manifestations of hepatitis?
    • -fever
    • -malaise
    • -fatigue
    • -anorexia
    • -abdominal pain
    • -reduced liver function
    • -elevated serum bilirubin concentration
  38. What are the complications of hepatitis?
    • -liver failure
    • - renal failure
    • -cerebral edema
    • -hemodynamic instability
    • -severe hypoglycemia
    • -immunosuppression
    • -cirrhosis
  39. What are the clinical manifestations of cirrhosis?
    • -jaundice
    • -portal hypertension
    • -ascites
    • - fatigue, malaise, weakness
    • -anorexia
    • -nausea and vomiting
    • -steatorrhea
    • -overall decline of the health and nutritional status
    • -failure to thrive
    • -hepatic encephalopathy and reduced mental functions
    • -diabetes mellitus
  40. Explain the purpose of nutrition care in liver disease
    • -support and maintain a normal nutritional status, including protein-energy and micronutrient status, using nutrition support if required
    • -prevent complications, including malnutrition, and worsening of metabolic abnormalities associated with hepatic disorders
    • -favor regeneration of hepatic tissue
    • -help support normal growth in children and adolescents
  41. Why are clients with liver disease at risk of protein-energy malnutrition?
    • -altered macronutrient metabolism
    • -anorexia
    • -nausea & vomting
    • -maldigestion and malabsorption
    • -reduced oral intake
  42. What is the best method to determine the energy needs of clients with liver disease?
    • -indirect calorimety
    • -CO2 / O2 exchange
    • -one liter oxygen = 4 calories
  43. Which biochemical data may help identify the presence of liver disease?
    • -AST
    • -ALT
    • - (ALP) alkaline phosphatase
    • - blood albumin concentration
    • -BUN
    • -PT time
    • -serum ammonia (increased in liver failure and hepatic encephalopathy)
    • - WBC
    • - C-reactive protein
    • -blood glucose
    • -blood lipid profile
  44. What other biochemical measures are useful in assessing the nutritional status of clients with liver disease?
    • - blood albumin concentration
    • -blood thyroxine-binding prealbumin concentration
    • -blood transferrin concentration
    • -total lymphocyte count
    • -blood hemoglobin concentration
    • -serum osmolarity
    • -serum electrolyte concentrations
    • -Hgb
    • -Hct
    • -MCV
    • -MCHC
    • -serum folate
    • -serum B12
    • serum thiamin
    • -serum Vitamin C
  45. What is the main dietary recommendation postcholecystectomy?
    - a fat restrticted diet (25-50g) in the first weeks/months and then a regular diet that is low in fat, as tolerated.
  46. How is alcoholic liver disease managed?
    with a mulitdisciplinary approach supporting the client and promising abstinence. The role of diet therapy is to provide adequate nutrition and nutrition support as required to maintain or improve the nutritional status.
  47. What diet is recommended for liver disorders such as hepatitis, cirrhosis, and biliray disease?
    • -has to be individualized for each client depending on the type of liver disease and its severity
    • -energy needs are usually increased due to infection, metabolic stress, surgery, and weight loss.
    • - supplemental nutrition help may be needed if the client cannot maintain a healthy nutrition status
  48. Which clients with liver disease are especially susceptable to fat maldigestion and, and therefore, may require a fat-restricted diet?
    • -cirrhosis
    • -reduced bile flow
    • -biliray tract obstruction
    • -alcoholism
    • -cholecystectomy
  49. When are fluid and sodium restrictions necessary in clients with liver disease?
    -clients with edema or ascites
  50. Which vitamins and minerals may need to be supplemented in clients with liver disease due to suboptimal status and possible deficiency?
    • - folate
    • -thiamin
    • -B6
    • -Vitamin C
    • - B12
    • -fat soluble vitamins (if steatorrhea)
  51. _________ is a synthetic nonabsorbable disaccharide used in the treatment of hepatic encephalopathy. It acts as a nonabsorbable fiber and is metabolized to lactate by bacteria in the colon. It acts as a laxative and favors ammonia and nitrogen excretion in the feces.
  52. Give the signs and symptoms of acute pancreatitis.
    • -acute abdominal pain in the LUQ
    • -N & V
    • -anorexia
    • - hematologic abnormalities including:
    • - increased blood amylase
    • -increased blood lipase
    • - elevated WBC
    • -lowered blood calcium
    • -elevated AST
    • -elevated BUN
    • -decreased Hct
    • -elevated blood glucose
    • -elevated blood triglyceride
  53. Describe the most severe complications of acture pancreatitis.
    fulminant pancreatic inflammation which progresses to necrotizing pancreatitis with liberation of the pancreatic enzymes, which can burn other tissues in the abdominal cavity
  54. What is medical nutrition therapy for clients with chronic pancreatitis?
    • -complete abstinence from alcohol
    • -maintainence of body weight
    • - high energy diet (25-30 kcals/kg/day)
    • -1.0 - 1.5 g protein/kg/day
    • - 40-60% of energy from CHO
    • - fat restricted if steatorrhea is present
    • -enzyme replacement therapy to reduce protein and fat maldigestion
    • -MCT oil
    • -restoration of nutrtional status with vitamin and mineral supplementation and nutrition support as needed
  55. What is the medical nutrition therapy for clients with acute pancreatitis?
    • -NPO
    • -intravenous fluids and electrolytes
    • -enteral nutrition in the jejunum
    • -parenteral nutrition if required due to complications
    • -oral intake restarted when the inflammation is resolved
  56. recurrent insults followed by repair of the liver tissue can cuase fibrosis and scarring known as _______, which involved an irreversible distortion of hepatocyte structure, usually occuring after long-term liver dysfunction.
  57. What is the effect of long-term alcohol abuse on the liver?
    the liver stores fat (fatty liver), hepatitis, cirrhosis
  58. Describe how hepatic steatosis may progress to cirrhosis.
    fat builds up, the liver cells enlarge, which can regenerate if drinking ceases, but it can lead to hepatitis and cirrhosis if drinking continues
  59. Differentiate between hepatitis A, B, C, D, E
    Hepatitis A: infectious virus, transferred via feces

    Hepatitis B: virus, transferred via blood, needles, body fluid

    Hepatitis C: virus, transfered via blood products

    Hepatitis D: virus serum hepatitis

    Hepatitis E: virus, transfered by contaminated water
  60. What is biliary cirrhosis?
    irreversible destruction of the liver tissue, obstruction of bile duct, bile builds up in the liver
  61. explain how advanced liver disease alters the metabolism of carbohydrate.
    decreased blood glucose, decreases glycogen storage capacity, increases fat build-up due to the lack of ability to convert CHO to fat, and convert glucose to glycogen and glycogen to useable glucose.
  62. explain how advanced liver disease alters the metabolism of Protein
    increases ammonia in the blood because the liver is needed to remove nitrogen from proteins and it helps make body proteins that serve many functions throughout the body including enzymes
  63. How is hepatic encephalopathy treated?
    • -lactulose which consumes some of the ammonia in the blood and excretes it with the feces
    • -decrease protein intake
  64. What are clinical manifestations of severe alcoholism?
    • -fatty liver
    • -gastritis
    • -pancreatitis
    • -deficiencies: thiamin, folate, B6, Vitamin C
  65. What diet therapy is recommended for the management of cystic fibrosis?
    • -enzyme replacement therapy
    • -increase energy, protein
    • -mineral and vitamin supplement
  66. ________ is synthesized by the liver and is the main blood protein. Therefore it can be used as a marker of liver function. Decreased _________ concentration in the blood is seen in liver disease. However, it is not a sensitive marker as its half-life is 12 to 18 days and it is not specific as other factors can alter its concentration including malnutrition, fluid status, inflammation & pregnancy.
  67. These conditions are associated with cholelithiasis formation except...
    A. rapid weight loss
    B. menopause
    C. prolonged fasting
    D. cystic fibrosis
    E. ileal resection
    B. menopause
    (this multiple choice question has been scrambled)
  68. disease-specific nutrition support formulas like Nutrihep and other hepatology formulas are usually lower in _________
    aromatic amino acids
  69. What are the dietary recommendations for clients with mild chronic cholecystitis with symptomatic gallstones?
    • -decreased fat diet (less than 30% kilocalories)
    • - evenly distributed fat throughout the day
    • - avoid gas-forming food (individual tolerances)
  70. What are the dietary recommendations for clients with acute cholecystitis with symptomatic gallstones awaiting an emergency cholecystectomy by laparoscopy?
Card Set
Liver disease
Diseases of the liver and pancreas
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