RNA.txt

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Author:
emm64
ID:
143000
Filename:
RNA.txt
Updated:
2012-03-21 18:20:37
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RNA Micro
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Description:
RNA Micro
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  1. Rhabdoviruses
    • (-)RNA, Helical Capsid
    • Rabies
    • - infection by animal bites
    • - invariably fatal without treatment
    • encephalitis
    • hydrophobia
    • neural degeneration
    • coma and death
    • anti-rabies Ab
    • The long incubation time allows immunization to generate antibody responses as a post-exposure treatment
  2. Filovirus
    • Filo = “threadlike”
    • Ebola virus
    • Marburg virus
    • Deadly hemorrhagic fever(60-90% fatality)
    • Contact with infected monkeys/humans or their tissues, secretions, or body fluids
  3. Paramyxoviruses
    • (-)RNA, envelope
    • Envelope glycoproteins
    • Fusion protein ->syncytia
  4. Respiratory syncytial virus (RSV)
    • bronchiolitis/pneumonia
    • (1st cause in infants)
  5. Parainfluenza
    • Paramyxo((-)RNA, envelope)
    • (1-4)
    • bronchiolitis/pneumonia
    • (2nd cause in infants)
  6. Measles
    • Paramyxo((-)RNA, envelope)
    • pneumonia Koplik’s spot (oral)
    • encephalitis rash
    • Vaccine : MMR
    • Highly contagious
    • Inhalation of respiratory droplet
    • Enters via oropharynx
    • systemic infection spread by viremia
    • Koplik’s spot - Small (1-2 mm), red spots with white speck in the center
    • Highly contagious, one major childhood disease
    • Complications
    • Pneumonia – very common (bacterial superinfection), 60% of deaths
    • Encephalitis – 1/1000, can cause deafness and mental retardation
    • Subacute sclerosing pan encephalitis (SSPE) – 1/3x105 , fatal
    • Giant cell pneumonia – in immuno-deficient children, often fatal
    • opt-out laws has lead to super-bowl outbreak
  7. Mumps
    • Paramyxo((-)RNA, envelope)
    • virus
    • Parotitis
    • (salivary gland)
    • Vaccine : MMR
    • Inhalation of droplets
    • Enters via pharynx
    • Systemic spread by viremia
    • Inflammation for symptoms
    • 30%-40% produce typical acute parotitis
    • CNS involvement (50%) meningitis
    • may be associated with onset of juvenile diabetes
    • Orchitis (testicular inflammation, 50%)
    • severe in adolescent and adult males, rarely cause sterility
    • Deafness, death
    • 2006 outbreak, 6k in 45 states Midwestern college
    • 2009 outbreak 3500 in NY/NJ
  8. Arenavirus (2)
    • segmented (-)RNA
    • Rodents
    • Lass Fever hemorrhagic
    • LCMV (Lymphocytic choriomeningitis virus)-rodent breeding/pet owners
  9. Bunyavirus (3)
    • segmented (-)RNA
    • Arbovirus
    • mosquitos, rodents
    • Hantavirus rodents, hemorrhagic fevers, pulmonary syndrome
  10. Orthomyxovirus (8)
    • segmented (-)RNA
    • humans, birds, pigs
    • influenza A(mammals and birds), B and C (mammals)
    • ENVELOPE
    • HA-hemagglutinin
    • NA-neuraminidase
    • 8 RNA segments
  11. Reassortment
    Mixing RNA genomes of 2 similar viruses which infect same cell
  12. Retroviruses
    • Enveloped
    • (-) RNA but produce DNA (reverse transcription)
    • Not segmented, but 2 copies of single-stranded RNA (same coding information)
  13. Lentivirinae Family
    • Retro
    • AIDS (immunosuppression)
    • Human Immunodeficiency virus (HIV)
  14. Oncovirinae
    • Retro
    • CD4+ T cells
    • Adult T-cell leukemia (cancers)
    • Human T-cell leukemia virus (HTLV)
  15. Spumavirinae
    • Retro
    • no disease
    • Human foamy virus
  16. Reovirus
    • Rotavirus
    • segmented dsRNA
    • non-enveloped
    • double-layered capsid
    • major cause of GE in infants/children
    • dehydration (600,000 deaths worldwide)
    • Malabsorbtion
    • Viral toxin NSP4-induce secretion

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