Pharm Final

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Author:
kskog09
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144105
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Pharm Final
Updated:
2012-03-29 20:30:13
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pharmacology
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pharmacology final review
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  1. abciximab
    • platelet inhibitor
    • binds between glycoprotein receptors
  2. acetylcholine
    cholinergic agonist-direct
  3. albuterol
    • beta2-adrenergic agonist
    • vasodilation, bronchodilation (asthma)
  4. alpha-methyldopa
    alpha2-adrenergic agonist
  5. aminocarproic acid
    • treatment of bleeding
    • promotes clot formation, prevents plasmin formation
  6. aspirin
    • platelet inhibitor
    • inhibits prostaglanind formation
  7. atenolol
    • beta1-blocker
    • used to treat cardiovascular diseases (angina, hypertension)
  8. atorvastatin
    • HMG-CoA reductase inhibitor
    • inhibits synthesis of chol
  9. atropine
    • antimuscarinic
    • cholinergic antagonist
  10. beclomethasone
    choinergic agonist-direct
  11. bethanechol
    cholinergic agonist-direct
  12. caffeine
    CNS stimulant
  13. cefotaxime
    • inhibitor of cell wall synthesis
    • inhibits peptidoglycan strands
  14. chloramphenicol
    protein synthesis inhibitors
  15. cholestyramine
    • bile acid sequestrant
    • increases excretion of cholesterol thru feces
  16. cimetidine
    H2-histamine blocker
  17. ciprofloxacin
    inhibitors of DNA gyrase
  18. clonidine
    • alpha2-adreneric agonist
    • presynaptic receptor (inhibits further NE release)
  19. clozapine
    neuroleptics, atypical
  20. dextromethophan
    cough suppressant
  21. diazepam
    • benzodiazepines
    • decreases excitability of certain areas of spinal cord and brain
  22. digoxin
    • ionotropic agents
    • digitalis
  23. diphenhydramine
    antihistamines
  24. dobutamine
    • beta1-adrenergic agonist
    • used to stimulate the heart
  25. enalapril
    • ACE inhibitors
    • will reduce afterload of heart (increasing cardiac output)
    • decreases preload (reduces peripheral edema)
  26. ephedrine
    adrenergic agonist
  27. epinephrine
    adrenergic agonist
  28. gemfibrozil
    • fibric acid agents
    • stimulate lipoprotein lipase activity (hydrolyzes TGs)
  29. erythromycin
    • protein synthesis inhibitors
    • binds to 50s, inhibits translocation
  30. gentamicin
    • inhibitor of protein synthesis
    • binds to 30s and distorts structure, thus inhibiting protein synthesis
    • narrow spectrum
  31. glipizide
    oral hypoglycemic
  32. heparin
    • anticoagulants
    • changes anti-thrombin III to interact with clotting factor
  33. hydralazine
    direct vasodilators
  34. hydrochlorothiazide
    • diuretics
    • lowers plasma volume and decreases workload of heart
  35. imipramine
    • TCAs (antidepressants)
    • drugs cause increase in neurtoransmitter NE and 5-HT
  36. insulin
    hypoglycemic
  37. lithium salts
    antimanics (bipolar)
  38. losartan
    • ARBs
    • angiotensin I receptor blocker
  39. methylphenidate
    CNS stimulants
  40. metoprolol
    • beta-blocker
    • prevent sympathetic compensatory response
  41. milrinone
    • ionotropic agents
    • phosphodiesterase inhibitor
  42. niacin
    • antihyperlipidemia
    • decreases VLDL levels and most potent at raising HDL
  43. nicotine
    ganglionic blockers
  44. nifedipine
    CaCh blocker
  45. nitroglycerin
    organic nitrate
  46. omeprazole
    proton pump inhibitor
  47. oxymetazoline
    alpha-adrenergic agonist (nasal decongestant)
  48. penicillin G
    • inhibitor of cell wall synthesis
    • acts by attaching to the PBP at the active site
    • prevents cross-link (making a non-functionable cell wall)
  49. phenelzine
    MAOIs
  50. phenobarbital
    • barbiturates
    • increases GABA effects
  51. phenylephrine
    • alpha1-adrenergic agonist
    • vasoconstriction (decrease b.p without affecting the heart)
  52. physostigmine
    • cholinergic agonist-indirect
    • hypotension, bradycardia
  53. prazosin
    • alpha1-blocker
    • used clinically to treat hypertension
  54. sulfisoxazole
    folic acid antagonist
  55. propranolol
    • beta-blocker
    • used to treat cardiovascular diseases (angina, hypertension)
  56. spironolactone
    diuretics
  57. streptokinase
    • thrombolytics
    • breaks clots, forms complex with plasminogen
  58. succinylcholine
    depolarizing cholinergic antagonist
  59. tetracycline
    • protein synthesis inhibitors
    • inhibit formation of protein synthesis by inhibiting tRNA
  60. ticlopidine
    • platelet inhibitors
    • ADP inhibitor
  61. trimethaphan
    ganglionic blockers
  62. tubocurarine
    non-depolarizing cholinergic antagonist
  63. vancomycin
    • inhibitors of cell wall synthesis
    • targets cell wall, interferes with cell membrane synthesis
  64. vitamin K
    treatment of bleeding
  65. warfarin
    • anticoagulants
    • wont synthesize clotting factors
  66. sedatives
    hypnotics
    tranquilizers
    • CNS depressant
    • induces sleep
    • produce a calming effect
  67. Treating depression
    drugs cause increase in neurotransmitter NE and 5-HT
  68. Mechanism of actions- SSRIs
    • selective serotonin reuptake inhibitors
    • inhibits reuptake of 5-HT
  69. Mechanism of action TCA's
    inhibit reuptake of NE and 5-HT
  70. Mechanism of action- MAOIs
    MAO breaks down the neurotransmitters NE, epinephrine, DA, and 5-HT (inhibits break down of N.Ts)
  71. Hemostasis
    the process of stopping blood flow
  72. singals from undamaged tissue (2 molecules)
    • prostacyclin
    • nitric oxide
    • inhibit platelet aggregation by formation of cAMP
  73. receptors on platelets bind:
    • thromnin
    • thromboxanes
    • exposed collagen
  74. molecules released from granules taht promote platelet activation
    TXA2, ADP, 5-HT, thrombin
  75. What is happening to the platelet which is part of the activation process
    change shape- release ADP, TXA2, 5-HT
  76. What do you call the aggregation of activated platelets at teh site of injury?
    hemolytic plug (primary plug)
  77. What initiates the coagulation cascade
    tissue facator expression (activated endothelial cells)
  78. The activation of what molecule is the culmination of the coagulation cascade?
    thrombin
  79. What protein polymerizes and cross-links around the site of injury and found in the definitive (secondary) hemostatic plug
    fibrin
  80. What molecules are considered natural anticoagulants, limiting the size of the plug
    PGI2, t-PA, nitric oxide, prostacyclin
  81. effects of blocking calcium channels
    • relaxation of smooth muscle (vasodilation)
    • negative ionotropic effects on heart (decreases force of contraction)
    • suppression of cardiac conduction
  82. Goal of drug therapy for asthma and COPD
    terminate acute bronchopasms and reduce frequency of attacks
  83. Antibiotics goal of therapy
    • disrupt the life cycle of the invading microorganism
    • bacteriocidal
    • bacteriostatic

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