S2M3 histo

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sweetlu
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144634
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S2M3 histo
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2012-04-07 15:49:51
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S2M3 histo
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S2M3 histo
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  1. primary oocytes
    - arrested in diplotene stage of prophase of meiosis 1 by OMI
  2. primordial follicle
    • -single layer of flattened follicular cells surrounding the primary oocyte (arrested in prophase of meiosis 1)
    • -balbania body- mtch and RNA binding proteins
    • - annulate lamella- similar to nuclear envelope
  3. primary follicle
    - unilaminar- single layer of cuboidal or columnar follicular cells

    - mulitlaminar- granulosa cells (proliferation due to activin)

    -stroma cells reorganize into theca folliculi
  4. zona pellucida
    • - protein coat that seperates oocyte from follicular cells
    • - ZP3 glycoprotein- sperm receptor and involved in acrosomal reaction
  5. theca folliculi
    - stromal cells around multilaminar follicle
  6. theca interna
    • - steroid producing cells
    • - contain LH receptors on membrane
    • - produce androstenedione
    • - (andriostenodione enters granulosa cell and is converted to estrogen( source of estrogen at puberty)
  7. secondary/ antral follicle
    • - accumulations of fluid known as liquor folliculi amoung granulosa cells
    • - granulosa accumulation depends on FSH
    • - FSH + estrogen => granulosa cells expressing LH receptors
  8. inhibin
    • M- secreted by Sertoli cells
    • F- secreted by granulosa cells
  9. activin
    • M- secreted by Sertolli cells
    • F- secreted by oocyte
  10. interstitial glands
    • - secrete estrogen untill menopause
    • - granulosa cells of atretic follicles
  11. mature Graafian follicle
    - single fluid filled antrum
  12. corona radiata
    - single layer of granulosa cells immediately surrounding the primary oocyte
  13. cumulus oophorus
    - mound of granulosa cells that surrounds and anchors the oocyte to the peripheral granulosa cells
  14. ovulation cause and 4 effects
    • - day 14, surge of E shuts off FSH and causes LH surge
    • LH surges causes
    • - 1oocyte completes meiosis 1 and newly formed 2oocyte enters meiosis 2 and stops in metaphase(roughly 3 hrs before ovulation)
    • - stigma formation==> opening into peritoneal cavity
    • - 2oocyte with CR are released into peritoneal cavity
    • - 2oocyte swept into fallopian tube by fimbrae (degeneration within 24 hrs if not fertilized)
  15. LH
    • - initiates puberty
    • - maintains corpus luteum
    • - responsible for ovulation and the changes in the oocyte during ovulation (M1 completion, oocyte release, etc)
  16. Corpus luteum
    • - 2 cells types (granulosa lutein (80% LIGHT) and theca lutein(20% DARK)
    • - secretes mainly progesterone (endometrium support and LH inhibition)
    • - also secretes estrogen(inhibits FSH)
    • - LH supports for ~first 10 days
    • - if fertlization occurs hCG will induce longer life
  17. Hilus cell
    • - in ovarian medulla
    • - secretes androgens (similar to leydig cells in males)
    • - can give rise to masculinizing tumor
  18. granulosa cells 6
    • - multilayer follicular cells stim by activin
    • - surround oocyte just outside of ZP
    • - convert androstenodione---->estrogen
    • - secretes estrogen
    • - when part of CL secretes mainly progesterone
    • - forms interstitial glands
  19. merkel cells
    • - touch receptors
    • - located in the stratum basale
    • - abundantin skin where sensory perception is acute
  20. pacinian corpuscle
    • - pressure and vibration sensors
    • - located in the hypodermis
    • - myelinated nerve ending surrounded by a corpuscle (that resembles an onion
    • - mechanically gated ion channel
  21. free nerve ending
    • -fine touch, heat, cold, pain and itch sensors
    • - terminate in the stratum granulosum
    • - surround most hair follicle and sensitive to hair movement
  22. meissners corpuscle
    • - touch recpetors
    • - in dermal papillae
    • - respond to slight deformation of the epidermis
    • -common areas sensitive to tactile stimulation (lips, nipples and external genetalia
    • - mechanically gated ion channel
  23. Ruffinis corpuscle
    • - stretch receptors (particularly sensitive to cutaneous stretching)
    • - found in hypodermis
    • - spindle shaped
    • - mechanically gated ion channel
  24. eccrine glands
    • - found all over the body in reticular layer of dermis
    • - secrete sweat
    • - SNS controlled myoepithelial cells at base and aid secretion
    • - important in thermoregulation
    • - simple coiled tubular glands that open into sweat pores
    • - duct(stratified cuboidal) is always darker than the gland(columnar)
  25. Apocrine gland
    • - found in the arm pit, areola and anal region
    • - secrete a viscous secretion and pheremones
    • - ducts open into hair follicles
    • - actually merocrine glands(secrete by exocytosis)
    • - very wide lumen

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