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What is the MOA of methotrexate?
blocks the actions of folic acid by blocking dihydrofolate reductase
blocks the synthesis of purines and DNA
What is the absorption of methotrexate?
100% for doses below 30 mg/m
What is the percentage of methotrexate bound to proteins?
What is the Vd of methotrexate? What type of compartment model does methotrexate follow?
What is the distribution 1/2 life of methotrexate? elimination 1/2 life?
With an increase or decrease in urine pH will you see methotrexate precipitate and cause nephrotoxicity?
What is leucovorin?
Restores folate stores needed for purine/pyrimidine synthesis
What is glucarpidase?
Drug that converts methotrexate to inactive metabolites
Used mainly in emergency situations when methotrexate is in toxic ranges--specifically for patients with impaired renal function
Must be separated from leucovorin by 2 hours
What are some side effects of methotrexate?
Inflammation of the GI tract
What is the goal methotrexate concentration?
< 0.1 micromolar by 48 hours following initiation
What is the percentage of absorption for busulfan?
What percentage of busulfan binds to plasma proteins? RBCs?
What type of metabolism do busulfan undergo?
What is sinusoidal obstructionsyndrome?
AKA veno-occlusive disease
Primary injury to liver due to supratherapeutic concentrations of Busulfan
Significant post-transplant complication leading to mortality
What is the target range of busulfan?