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What class of drugs do not undergo CYP metabolism?
What NRTI has the best placental penetration?
How are NRTIs cleared?
Renally except abacavir and ZDV
What NNRTI has to be taken on an empty stomach due to increased absorption with high fat meals?
What NNRTI needs to be taken with a meal with greater than 500 calories for adequate absorption?
What is the 1/2 life of NNRTIs?
Are NNRTIs cleared renally?
Are protease inhibitors substrates for P-gp or CYP 3A4?
What drugs have high 1st past metabolism and low bioavailability?
Which protease inhibitor is a P-gp inhibitor?
What is special about atazanavir?
Needs acid to be absorbed
How is enfuvirtide given?
Substrate of P-gp and CYP 450
What drug/drug class is metabolized via glucuronidation?
Integrase inhibitors (raltegravir)
What is the interation between Tenofovir(TDF) and atazanavir?
- Decreated [ATV]
- Always boost with ritonavir
EFV/NVP + Rifampin
- Decreased [EFV/NVP]
- Increase EFV dose
EFV/NVP + statins
- Decreased concentration of statins
- Monitor cholesterol, may need to be more agressive
What drug is contraindicated with rilpivirine?
Proton Pump inhibitors
List the drugs that are contraindicated with protease inhibitors
- Ergot derivatives
- St. John's wort
ATV + PPI
- Decreased ATV
- MAX dose of omeprazole 20 mg
- boost with ritonavir if naieve
PIs+ amiodarone, lidocaine, quinidine, bepridil
- Increased concentration of antiarrhthmics
- Avoid if possible
PIs + trazodone
- Increased [trazodone]
- start with lowest dose or cut current dose initially
PIs + immunosuppressants
- increased immunnosuppressants
PIs + statins
- Increased statin
- Use pravastatin or atorvastatin
Maraviroc (MVC) + inducers
- decrease MVC
- double dose of MVC
MVC + inhibitors
- Increase MVC
- Give 1/2 of usual MVC dose
Raltegravir + rifampin
- Decrease raltegravir
- Double usual dose
Raltegravir + phenytoin/phenobarb
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