BIO142

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Author:
highmonkees
ID:
145142
Filename:
BIO142
Updated:
2012-04-01 21:41:24
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Respiratory Care Pharmacology
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Description:
BIO142 Final Exam Review-Unit 1
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  1. The only antileukotriene agent currently approved for use in pediatric patients is:

    A) Tilade.
    B) Accolate.
    C) Intal.
    D) Singulair.
    D) Singulair
    (this multiple choice question has been scrambled)
  2. Zileuton interacts with which of the following respiratory care drugs?
    I. Theophylline
    II. Albuterol
    III. Warfarin
    IV. Ipratropium bromide
    V. Beclomethasone
    I and III only
  3. A patient complains of oral thrush and hoarseness since she has been using fluticasone by MDI. The physician asks you to make a suggestion to help her without discontinuing the drug. You suggest:

    A) inhale with a higher inspiratory flow rate.
    B) switch to a DPI.
    C) add a spacer and rinse the mouth after use.
    D) pause 5 minutes between puffs.
    C) add a spacer and rinse the mouth after use
    (this multiple choice question has been scrambled)
  4. Leukotrienes exhibit which of the following effects?
    I. Increased mucus secretion.
    II. Inhibition of normal ciliary action.
    III. Increased airway edema.
    IV. Bronchoconstriction
    V. Recruitment of other inflammatory cells into airways.
    I, II, III, IV, and V
  5. The term used to describe surfactant produced outside of the patient's body is:

    A) bovine
    B) natural.
    C) endogenous.
    D) exogenous.
    D) exogenous
    (this multiple choice question has been scrambled)
  6. Surfactant is stored in:

    A) alveoli.
    B) Type II alveolar cells.
    C) lamellar bodies.
    D) lipids.
    C) lamellar bodies.
    (this multiple choice question has been scrambled)
  7. Tilade is effective as an antiinflammatory by inhibiting activation and activity of which of the following?
    I. Sensory neurons
    II. Mast cells
    III. Airway epithelial cells
    IV. Eosinophils
    I, II, III, and IV
  8. Which of the following nonsteroidal antiasthma agents is formulated as an MDI?

    A) Montelukast
    B) Zileuton
    C) Nedocromil
    D) Zafirlukast
    C) Nedocromil
    (this multiple choice question has been scrambled)
  9. Which type of asthma is associated with allergic reactions?

    A) Intrinsic
    B) Extrinsic
    C) Chronic
    D) Acute
    B) Extrinsic
    (this multiple choice question has been scrambled)
  10. Which drug is a lipid-soluble, intracellular receptor agonist that prevents an inflammatory response?

    A) Xolair
    B) Singulair
    C) Zyflo
    D) Flovent
    D) Flovent
    (this multiple choice question has been scrambled)
  11. All the following are considered natural surfactants except:

    A) Poractant alfa.
    B) Dornase alfa.
    C) Beractant.
    D) Calfactant.
    B) Dornase alfa.
    (this multiple choice question has been scrambled)
  12. The brand name for cromolyn sodium is:

    A) Accolate
    B) Tilade
    C) Singulair
    D) Intal
    D) Intal
    (this multiple choice question has been scrambled)
  13. You are in the room of a 26-week gestational baby that has just been born. The newborn weighs 1200 g. On assessment you find the baby has poor color, substernal retractions, nasal flaring, a RR of 45 breaths/min, and a HR of 140 beats/min. You note that the baby is difficult to bag. Which of the following agents would you recommend?

    A) Cromolyn sodium
    B) Beractant
    C) Albuterol
    D) Solu-Medrol
    B) Beractant
    (this multiple choice question has been scrambled)
  14. You are in the room of a 36-week gestational baby that has just been born. The newborn weighs 2200 g. On assessment you find the baby has good color, no retractions, no nasal flaring, a respiratory rate (RR) of 25 breaths/min, a heart rate (HR) of 110 beats/min, and pulse-ox of 96% on room air. Which of the following would you choose?

    A) No indication for drug therapy at this time
    B) Albuterol
    C) Calfactant
    D) Beractant
    A) No indication for drug therapy at this time
    (this multiple choice question has been scrambled)
  15. Which of the following are examples of steroids available for inhalation?
    I. Flunisolide
    II. Azmacort
    III. QVAR
    IV. Interleukin
    I, II, and III only
  16. Which of the following are natural surfactant preparations?
    I. Surfaxin
    II. Curosurf
    III. Survanta
    IV. Infasurf
    II, III and IV
  17. Another name for surface-active agents is:

    A) detergent.
    B) mucolytic.
    C) bronchodilator.
    D) antibiotic.
    A) detergent.
    (this multiple choice question has been scrambled)
  18. It has been suggested that Intal and Tilade are effective as antiinflammatory agents by blocking transport of what ion into inflammatory cells?

    A) Sodium
    B) Bicarbonate
    C) Potassium
    D) Chloride
    D) Chloride
    (this multiple choice question has been scrambled)
  19. Which of the following is considered the mode of action for surfactant?

    A) To relax bronchial smooth muscle.
    B) To emulsify lung secretions.
    C) To replace missing surfactant.
    D) To accelerate lung maturity.
    C) To replace missing surfactant.
    (this multiple choice question has been scrambled)
  20. The product combining an inhaled steroid and a bronchodilator is:

    A) QVAR.
    B) Flovent.
    C) Advair.
    D) Azmacort.
    C) Advair.
    (this multiple choice question has been scrambled)
  21. Side effects of systemic steroid treatment include which of the following?

    I. HPA suppression
    II. Cough
    III. Dysphonia
    IV. Psychiatric reactions
    I and IV only
  22. The usual method of administering exogenous surfactant to babies is:

    A) rectal suppository.
    B) nebulization.
    C) intravenously.
    D) direct instillation to the airway.
    D) direct instillation to the airway.
    (this multiple choice question has been scrambled)
  23. A significant side effect of corticosteroid use is inhibition of:

    A) HPA axis.
    B) SRS-A.
    C) IgE.
    D) PGE.
    A) HPA axis.
    (this multiple choice question has been scrambled)
  24. Cromolyn sodium is available in all of the following forms except:

    A) MDI
    B) Nasal spray
    C) Tablet
    D) Nebulizer solution
    C) Tablet
    (this multiple choice question has been scrambled)
  25. Which of the following are antileukotrienes?

    I. Zafirlukast
    II. Zileuton
    III. Cromolyn sodium
    IV. Montelukast
    V. Nedocromil sodium
    I, II, and IV only
  26. Which of the following is considered a mast cell stabilizer?

    A) Zafirlukast
    B) Zileuton
    C) Montelukast
    D) Cromolyn sodium
    D) Cromolyn sodium
    (this multiple choice question has been scrambled)
  27. Advantages to the use of antileukotrienes include all of the following except:

    A) effective in more than 90% of patients.
    B) oral administration.
    C) a formulation available for pediatric use.
    D) additive effect with inhaled steroids.
    A) effective in more than 90% of patients.
    (this multiple choice question has been scrambled)
  28. The usual dose of nebulized cromolyn sodium is:

    A) 30 mg three times per day.
    B) 20 mg four times per day.
    C) 80 mg three times per day.
    D) 10 mg four times per day.
    B) 20 mg four times per day.
    (this multiple choice question has been scrambled)
  29. The most commonly reported side effect of cromolyn sodium is:

    A) diarrhea.
    B) headache.
    C) nasal congestion.
    D) pneumonia.
    C) nasal congestion.
    (this multiple choice question has been scrambled)
  30. Which of the following is a monoclonal antibody used to treat asthma?

    A) Montelukast
    B) Nedocromil
    C) Omalizumab
    D) Zileuton
    C) Omalizumab
    (this multiple choice question has been scrambled)
  31. The inflammatory process includes which of the following activities?

    I. Mediator cascade
    II. Increased vascular permeability
    III. Leukocytic infiltration
    IV. Phagocytosis
    I, II, III, and IV
  32. For an alveolus, LaPlace's Law is written as:

    A) Pressure = surface tension/radius
    B) dyn/cm
    C) Pressure = ( 4 x surface tension)/radius
    D) Pressure = (2 x surface tension)/radius
    D) Pressure = (2 x surface tension)/radius
    (this multiple choice question has been scrambled)
  33. A newborn baby weighing 1000 g exhibits symptoms of respiratory distress syndrome (RDS), including poor color, suprasternal retractions, nasal flaring, and desaturation. The therapist should recommend:

    A) Poractant alfa.
    B) Dornase alfa.
    C) Ipratropium bromide.
    D) Salmeterol.
    A) Poractant alfa.
    (this multiple choice question has been scrambled)
  34. What is the clinical indication for use of leukotriene modifiers, such as montelukast, in asthma?

    A) As a mast cell stabilizer.
    B) As a long-acting bronchodilator in step 3 asthma.
    C) As an alternative to, or in combination with, inhaled steroids.
    D) As a rescue bronchodilator in step 1 asthma.
    C) As an alternative to, or in combination with, inhaled steroids.
    (this multiple choice question has been scrambled)
  35. The major stimulus for secretion of surfactant into the alveolus is:

    A) lung inflation.
    B) lung deflation.
    C) cough.
    D) infection.
    A) lung inflation.
    (this multiple choice question has been scrambled)
  36. Natural surfactant is obtained by all of the following methods except:

    A) in vitro preparation.
    B) animal alveolar wash.
    C) amniotic fluid extraction.
    D) human alveolar wash.
    A) in vitro preparation.
    (this multiple choice question has been scrambled)
  37. In chronic obstructive pulmonary disease (COPD., the primary inflammatory cells are:

    A) T lymphocytes.
    B) macrophages.
    C) eosinophils.
    D) neutrophils.
    D) neutrophils.
    (this multiple choice question has been scrambled)
  38. Nedocromil sodium is administered by:

    A) DPI.
    B) tablet.
    C) MDI
    D) nebulizer
    C) MDI
    (this multiple choice question has been scrambled)
  39. The rise and fall of levels of glucocorticoids in the body follows what kind of rhythm?

    A) Monthly
    B) Circadian
    C) No set rhythm
    D) Weekly
    B) Circadian
    (this multiple choice question has been scrambled)
  40. Zafirlukast is a:

    A) Adrenergic.
    B) corticosteroid.
    C) leukotriene receptor antagonist.
    D) leukotriene receptor stimulator.
    C) leukotriene receptor antagonist.
    (this multiple choice question has been scrambled)
  41. The major cells responsible for an inflammatory response in asthma are:

    A) mast cells and eosinophils.
    B) basophils and SRS-A.
    C) macrophages and mast cells.
    D) T lymphocytes and macrophages.
    A) mast cells and eosinophils.
    (this multiple choice question has been scrambled)
  42. All of the following are types of corticosteroids produced in the adrenal cortex except:

    A) sex hormones.
    B) corticotropin-releasing factor.
    C) glucocorticoids.
    D) mineralocorticoids.
    B) corticotropin-releasing factor.
    (this multiple choice question has been scrambled)
  43. Surfactant is composed primarily of:

    A) neutral lipids.
    B) proteins.
    C) phospholipids.
    D) water.
    C) phospholipids.
    (this multiple choice question has been scrambled)
  44. All the following are hazards or complications of exogenous surfactant except:

    A) airway occlusion.
    B) overoxygenation.
    C) pulmonary insult via barotraumas.
    D) tachycardia.
    D) tachycardia.
    (this multiple choice question has been scrambled)
  45. Corticosteroids normally produced by the body are known as:

    A) extrinsic.
    B) exogenous.
    C) intrinsic.
    D) endogenous.
    D) endogenous.
    (this multiple choice question has been scrambled)
  46. The general indication for clinical use of nonsteroidal antiasthma agents is:

    A) long-term control of bronchospasm.
    B) control of severe asthma attack.
    C) prophylactic management of mild persistent asthma.
    D) short-term control of bronchospasm.
    C) prophylactic management of mild persistent asthma.
    (this multiple choice question has been scrambled)
  47. Side effects of aerosolized steroid use include all of the following except:

    A) dysphonia.
    B) cough.
    C) oral thrush.
    D) osteoporosis.
    D) osteoporosis.
    (this multiple choice question has been scrambled)
  48. Which of the following are approved indications for surfactant therapy?

    I. Prophylaxis in very low birth weight (<1250 g) infants
    II. Prophylaxis in infants of higher birth weight (>1250 g) but with immature lungs
    III. Rescue treatment in infants with respiratory distress syndrome
    IV. Acute respiratory distress syndrome in the adult
    I, II, and III only
  49. Lack of pulmonary surfactant in respiratory distress syndrome of the newborn results in:

    A) high surface tension.
    B) no effect on surface tension.
    C) low surface tension.
    D) increased compliance.
    A) high surface tension
    (this multiple choice question has been scrambled)
  50. Surfactant is produced by:

    A) goblet cells.
    B) alveolar type I cells.
    C) alveolar type II cells.
    D) macrophages.
    C) alveolar type II cells.
    (this multiple choice question has been scrambled)

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