Name different IEGs.
How are they induced and how quickly?
Zif268 : It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity
- ARC: Changes in Arc mRNA and/or protein are correlated with a number of behavioral paradigms including fear conditioning. The mRNA is notably upregulated following electical stimulation in LTP-induction procedures such as high frequency stimulation (HFS), and is massively and globally induced by maximal electroconvulsive shock (MECS).
- The Arc transcript is the first known IEG that is entirely dependent upon activation of the mitogen-activated protein kinase or MAP kinase (MAPK) cascade, a pathway important for regulation of cell growth and survival.
nPas4: Early IEG that induces other IEGS.
C-Fos: Neuroscientists measure expression of c-fos as an indirect marker of neuronal activity because c-fos is often expressed when neurons fire action potentials. Upregulation of c-fos mRNA in a neuron indicates recent activity