Positive chronotropic drugs may potentiate tachycardia
Dosage and Administration
Adult: 0.1mg/kg slow IV; repeat every 30-60 minutes PRN.
Pediatric: 0.1mg/kg slow IV, IO
Duration of action
onset: 30 seconds
Peak effect: paralysis in 3-5 minutes
Duration: 45-60 minutes
Pregnancy safety: not established. If Pt. is conscious, explain the effect of the medication before administration and always sedate the Pt. before using pancuronium. Intubation and ventilatory support must be readily available. Monitor the Pt. carefully. Effects may be reversed with neostagmine (prostigmin) 0.05 mg/kg and should be accompanied by atropine (0.5-1.2 mg IV). Pancuronium has no effect on consciousness or pain. Will not stop neuronal seizure activity. Pulse rate, cardiac output are increased. Decrease doses for Pts. with renal failure.