Disorders of Coagulation and Platelets
- Hemophilia is a condition characterized by impairment of the coagulation of blood and a subsequent tendency to bleed. The classic disease is hereditary and limited to males, being transmitted through the female to the second generation. Many similar conditions attributable to the absence of various clotting factors are now recognized.
- The acquired antibody-mediated hemorrhagic diseases include idiopathic thrombocytopenic purpura (ITP), transient neonatal thrombocytopenia, and autoimmune vascular purpura.
- ITP, the most common of the childhood thrombocytopenic purpuras, is a disorder of platelet consumption in which antiplatelet antibodies bind to the plasma membranes of platelets. This results in platelet sequestration and destruction by mononuclear phagocytes at a rate that exceeds the ability of the bone marrow to produce them.