Infection, Immunity, Inflammation, and Cancer
- A number of viruses can cause cancer. Human cervical cancer is caused by papollomavirus infection. Kaposi sarcoma is caused by infection with a member of the herpesvirus family. Chronic hepatitis B or C infection can cause liver cancer.
- Immune system defects, such as those caused by immunosuppressant drugs or HIV infection, increase the risk of viral-associated cancers, such as EBV-associated lymphomas and cervical cancer.
- Chronic inflammation contributes to the development of cancer by stimulating increased proliferation and angiogenesis. Chronic hepatitis and colitis are two examples where chronic inflammation markedly increases the risk of cancer.