Patho Chapter 2
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nonspecific response to tissue injury
Inflammation occurs only in _______ tissue
3 causes of inflammation
- pathogenic orgamisms
Cardinal signs of inflammation in order of occurence
- Loss of function/Altered function
Tissue injury causes immediate ________ of the arterioles and is the body's first response to injury.
After vasoconstriction of the arterioles, mast cells and platelets release _____ _______ into interstital fluid and blood.
What do chemical mediators affect?
vessels and nerves
What happens as a result of chemical mediators?
- hyperemia(heat &redness)
first phagocytic cells to arrive at injury site?
response to bacterial infection
large number of leukocytes
Normal range of WBC?
inflammation with pus formation
Occurs around hair folllicle
caused by Staphyloccus aureus
local pocket of pus in solid tissue
swelling of eyelid glands
What WBC is increased in allergic reactions
ESR (elevated erythrocyte sedimentation rate)
- nonspecific diagnostic test
- ^ plasma proteins=^RBC
CRP (elevated serum C-reactive protein)
- diagnostic test
- protein made by liver that is increased after inflammatory stimulus
special form of chronic inflammation that is not preceded by acute inflammation
Which exudate(pus) has more lymphocytes, plasma cells, and macrophages?
Healing process that occurs with minimal damage
Damaged cells recover and tissue returns to normal
Which cells secrete histamine? Choose 2
basophils and mast cells
Which cells are phagocytoic?
Movement of leukocytes into interstitial space
Bands of scar tissue between 2 normally seperate surfaces
What type of cells becomes a macrophage once it has migrated into tissue?
What are the first cells to migrate to a site after injury?
What type of cell is prevalent in allergic response?
What is the term for hypertrophic scar?
What cells are prevalent in chronic inflammation?
What is the second event in the vascular response of inflammation?
What would be elevated during an acute inflammation of a large area?
3. body temp
4. platelet count
5. C-reactive protein level
- body temp
- C-reactive protein level
Which of the following could stimulate inflammation?
2. heart attack
3. throat infection
4. cat scratch
5. superficial burn
All of the above
The body's local response to tissue injury?
A protein, produced by fibroblasts, that is the basic component of scar tissue and provides strength for the new repair
The process by which leukocytes are attracted y chemical mediators at the site of the injury
Cells lost through injury must be replaced by mitosis
Complete return of normal structure and function
Accelerated mitotic rate to replace lost tissue
Which tissue and muscle cannot reproduce by mitosis?
- Nervous tissue
- cardiac muscle
- skeletal muscle
When cells are destroyed and cannot be reproduced, nearby cells hypertrophy to compensate. The loss of permanent tissue is followed by
Most important cells during reconstructive phase of wound healing
What do fibroblasts synthesize and secrete
basic component of scar tissue
When CT fibers attach to nearby tissue during healing
Hard, raised scar tissue
What type of healing:
Repair by scar or fibrous tissue
Repair begins as tissue grows inward from surrounding healthy CT
Temporary makeshift structure
CT rich in macrophages and fibroblasts
highly vascular, new capillaries form from endothelial cells
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