S2M3 CANCER

Card Set Information

Author:
sweetlu
ID:
146107
Filename:
S2M3 CANCER
Updated:
2012-04-06 16:26:07
Tags:
S2M3 CANCER
Folders:

Description:
S2M3CANCER
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user sweetlu on FreezingBlue Flashcards. What would you like to do?


  1. HER2
    • - overexpressed in many human breast cancers
    • - mutations leading to overexpression cause activation in the presence of very low [EGF]

    -accurate testing allows for appropriate Herceptin tx
  2. Ras
    • - aa for gly sub at pos 12 = dec GTPase act=oncogene
    • - signal transduction protein=>MAP activation=> nuclear TF activation
    • - active when bound to GTP
    • - GAP helps inactivate by speeding GTP->GDP hydrolysis
    • -
  3. c-Fos and c-Mys
    -stimulate transcription of genes that will promote progression thru G1 phase and G1-> S transition
  4. tumor supressor genes
    • - inherited mutations of only a single allele increases likely hood of tumor development to almost 100%
    • - RB- retinoblastoma
    • - APC- colon cancer
    • - BRCA1- breast cancer
  5. HK-2
    • - hexokinase 2
    • - utilized by cancer cells to produce ATP
    • - HK-2 binds to VDAC(on mtch) and can make ATP
    • - also prevents apoptosis inducing factor release (AIF)
  6. HIF
    • - hypoxia inducible factor
    • - essential for metabolic changes required for cancer to remain alive as its size increases

What would you like to do?

Home > Flashcards > Print Preview