Med chem diabetes

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  1. Sulfonylureas
    Stimulate insulin secretion from beta cells by blocking K+ channel.
  2. Tolazamide/Tolinase
    Sulfonylureas, 1st generation, t1/2 7hrs
  3. Tolbutamide/Orinase
    Sulfonylureas, 1st, 4.5-6.5 hrs, no active metabolite.
  4. Chlorpropamide/Diabinese
    Sulfonylureas, 1st, 36 hrs, active metabolite
  5. Acetohexamide/Dymelor
    Sulfonylureas, 1st, 6-8hrs, active met.
  6. Glipizide/Glucotrol
    Sulfony., 2nd, 2-4hrs, no active met.
  7. Glyburide/Diabeta
    Sulfony. 2nd, nonmicronized 10hrs, weakly active met.

    Micronized 4hrs.
  8. Glimepiride/Amaryl
    Sulfony. 3rd, 9hrs, active met. Cause translocation of the GLUT-4, and binds to a different protein then normal Sulfony.
  9. Rosiglitazone/Avandia
    Oral Thiazolidinediones, Type 2, works in the presence of insulin. Increase tissue sensitivity by increasing PPAR activity. Possible hepatic failure.
  10. Pioglitazone/Actos
    Oral Thiaz. Metabolized by 3A4, decreases oral contra.
  11. Repaglinide/Prandin
    Type 2, Non-Sulfonylurea analog, Stimulates insulin secretion.
  12. Metformin/Glucophage
    Type 2, decrease hepatic gluconeogenesis, decrease GI glucose absorption, increase peripheral insulin sensitivity.
  13. Nateglinide/starlix
    Type 2, stimulate insulin release
  14. Acarbose/Precose
    Type 2 as an adjunct to Sulfony or insulin, decrease carbo absorption by inhibiting alfa-glucosidase. Take with first bite of food!
  15. Glipizide and Metformin
  16. Rosiglitazone and Metformin
  17. Glyburide and Metformin
  18. Rosiglitazone and Glimepiride
  19. Pioglitazone and Metformin
  20. Repaglinide and Metformin
  21. Insulin glulisine/Apidra
    Recomb, rapid acting, Produced in Ecoli
  22. Insulin Determir/Levemir
    Recomb, long acting 24hr, also undergoes chemical mod with a fatty acid.
  23. Insulin glargine/Lantus
    Recomb, Forms microprecipitates in sub Q tissue prolonging duration 18-26hrs
  24. Insulin aspart/Novolog
    Recomb, rapid acting 3-5 hrs take before meal.
  25. Insulin lispro/Humalog
    Recomb, rapid acting 3-5 hrs, take before or immediatly after meal.
  26. Exenatide/ Byetta
    Synthetic, incretin or glucagon-like peptide, increases insulin synthesis and exretion.
  27. Pramlintide/Symlin
    synthetic analog of human anylin
  28. Liraglutide/Victoza
    incretin or glucagon-like peptide. Risk of thyroid c-cell tumor.
  29. Sitagliptin/Januvia
    DPP-IV inhibitor, Prolongs levels of natural incretins and increases insulin release
  30. Saxagliptin/Onglyza
    DDP-4 inhibitor, Adverse=decrease lymph count, hypoglycemia, headaches.
  31. Linagliptin/Tradjenta
    Not for type 1, subsstrate for P-glyco, inducer of 3A4
  32. Bromocriptine/Cycloset
    type 2 only, improve glycemic control, increases dopamine levels.
  33. Becaplermin/Regranex
    Human durived platelet growth factor, used to treat diabetic neuropathic ulcers, topical gel
  34. Welchol/ Colesevelam
    Bile acid sequestrant, improves glycemic control.
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Med chem diabetes
diabetes quiz
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