Med chem diabetes
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Med chem diabetes
Med chem diabetes quiz
Stimulate insulin secretion from beta cells by blocking K+ channel.
Sulfonylureas, 1st generation, t1/2 7hrs
Sulfonylureas, 1st, 4.5-6.5 hrs, no active metabolite.
Sulfonylureas, 1st, 36 hrs, active metabolite
Sulfonylureas, 1st, 6-8hrs, active met.
Sulfony., 2nd, 2-4hrs, no active met.
Sulfony. 2nd, nonmicronized 10hrs, weakly active met.
Sulfony. 3rd, 9hrs, active met. Cause translocation of the GLUT-4, and binds to a different protein then normal Sulfony.
Oral Thiazolidinediones, Type 2, works in the presence of insulin. Increase tissue sensitivity by increasing PPAR activity. Possible hepatic failure.
Oral Thiaz. Metabolized by 3A4, decreases oral contra.
Type 2, Non-Sulfonylurea analog, Stimulates insulin secretion.
Type 2, decrease hepatic gluconeogenesis, decrease GI glucose absorption, increase peripheral insulin sensitivity.
Type 2, stimulate insulin release
Type 2 as an adjunct to Sulfony or insulin, decrease carbo absorption by inhibiting alfa-glucosidase. Take with first bite of food!
Glipizide and Metformin
Rosiglitazone and Metformin
Glyburide and Metformin
Rosiglitazone and Glimepiride
Pioglitazone and Metformin
Repaglinide and Metformin
Recomb, rapid acting, Produced in Ecoli
Recomb, long acting 24hr, also undergoes chemical mod with a fatty acid.
Recomb, Forms microprecipitates in sub Q tissue prolonging duration 18-26hrs
Recomb, rapid acting 3-5 hrs take before meal.
Recomb, rapid acting 3-5 hrs, take before or immediatly after meal.
Synthetic, incretin or glucagon-like peptide, increases insulin synthesis and exretion.
synthetic analog of human anylin
incretin or glucagon-like peptide. Risk of thyroid c-cell tumor.
DPP-IV inhibitor, Prolongs levels of natural incretins and increases insulin release
DDP-4 inhibitor, Adverse=decrease lymph count, hypoglycemia, headaches.
Not for type 1, subsstrate for P-glyco, inducer of 3A4
type 2 only, improve glycemic control, increases dopamine levels.
Human durived platelet growth factor, used to treat diabetic neuropathic ulcers, topical gel
Bile acid sequestrant, improves glycemic control.