Prostate Cancer

Card Set Information

Author:
capnhue
ID:
146717
Filename:
Prostate Cancer
Updated:
2012-04-27 00:04:56
Tags:
Regis University
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Description:
Prostate Cancer
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  1. High Risk using Androgen Deprivation Therapy (ADT)
    • osteoporosis
    • insulin resistance
    • hypercholesterolemia
    • obesity
    • cardiovascular disease
    • depression
    • gynecomastia
    • hot flashes
  2. LHRH adverse effects
    • hot flashes
    • erectile dysfunction and impotence
    • decreased libido and depression
    • injection-site reactions
  3. antiandrogen adverse effects
    • gynecomastia
    • hot flashes
    • breast tenderness
    • GI (diarrhea, constipation)
    • Liver function abnormalities (LFT)
  4. Flutamide black box warning
    hepatic injury
  5. Nilutamide black box warning
    • interstitial pneumonitis - can lead to pulmonary fibrosis
    • symptoms: cough, dyspena upon exertion, chest pain, fever
  6. Docetaxel Toxicity
    • Acute toxicity: hypersensitivity
    • Delayed toxicity: Neurotoxicity/peripheral neuropathy, fluid retention, myleosuppression w/neutropenia
    • *treat fluid retention w/dexamethasone
  7. Estramustine adverse effects
    • myelosuppression
    • estradiol-related effects: thrombosis, gynecomastia, impotence, fluid retention
  8. Localized Symptoms of Prostate Cancer
    • Stage I-II
    • confined to prostate
    • asymptomatic
  9. Locally Invasive Symptoms of Prostate Cancer
    • Stage III
    • spread just beyond prostate (semincal vesicles)
    • Ureteral dysfuntion: frequency, hesitantcy, dribbling
    • Blood in urine/specimen: hematuria
    • impotence
  10. Advanced Disease Symptoms of Prostate Cancer
    • Stage IV
    • spread to lumbar spine, liver, lungs, brain
    • back pain
    • cord compression
    • lower-extremity edema
    • anemia
    • pathologic fractures
    • weight loss

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