Pharm Test 2

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Author:
Anonymous
ID:
146893
Filename:
Pharm Test 2
Updated:
2012-04-10 21:34:52
Tags:
Pharm Test
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Pharm Test 2
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  1. Histamine
    • Endogenous compund
    • found in specialized cells
    • important for allergic reation and regulation of gastric acid secretion
  2. In an allergic reacion histamines cause...
    • vasodilation
    • itching
    • edema
  3. H1 Receptors
    • vasodilation (skin on face and upper body) -extensive can cause hypotension
    • -part of anaphylatic reacion
    • capillary permeability causes edema (lips, eyes)
    • bronchoconstriction
    • CNS effects- role in cognition, memory, and sleep/waking cycles
    • other- itching, pain, secretion of mucus (hives)
    • usually antihistamines
  4. H2 Receptors
    • secretion of gastric acid - located in stomach
    • act directly on parietal cells to promote acid release
    • dominant role in acid release
  5. Histamine Antagonists/ Antihistamines
    • act primarliy on H1 & H2 receptors
    • used primarily for two patolgic states
    • 1. allergic disorders
    • 2. peptic ulcer disease
  6. allergic responses
    • mediated by histamine and other compounds
    • -prostaglandins
    • leukotrienes
    • tryptase

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