DA4 EXAM 3 DRUGS

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HUSOP2014
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146920
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DA4 EXAM 3 DRUGS
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2012-04-19 23:54:19
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HUSOP DA Exam3
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drug action 4 test 3 drugs
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  1. 1. glucocorticoids
    • o immunosuppressant - inhibitor of gene expression
    • o increases IkB expression, thereby curtailing activation of NFkB, which increases apoptosis of activated cells.
    • o Downregulates expression of IL-1, IL-2, IL-4, IL-6, TNFa
    • o T cells are inhibited from making IL-2 and proliferating
    • o anti-thyroid adjuvant
  2. 2. basiliximab
    • o Immunosuppressant
    • o anti-CD25, IL-2 antagonist
  3. 3. daclizumab
    • o Immunosuppressant
    • o anti-CD25, IL-2 antagonist
  4. 4. sirolimus
    • o Immunosuppressant
    • o mTOR inhibitor by binding FKBP-12, inhibits proliferation
  5. 5. everolimus
    • o Immunosuppressant
    • o mTOR inhibitor by binding FKBP-12, inhibits proliferation
  6. 6. azathioprine
    • o cytotoxic immunosuppressant
    • o purine synthesis inhibitor
    • o prodrug, aza to 6-MP to T-IMP (inhibits IMPDH) to 6-TGMP (encorporates in DNA)
  7. 7. methotrexate
    • o cytotoxic immunosuppressant/anti-RA
    • o inhibits dihydrate folate reductase (DHFR)
  8. 8. mycophenolate mofetil
    • o cytotoxic immunosuppressant
    • o prodrug, MMF to MPA, inhibits IMPDH type 2 (enzyme for guanosine formation)
  9. 9. cyclosporine (CsA)
    • o immunosuppressant
    • o calcineurin inhibitor by binding cyclophilin, downregulates IL-2
  10. 10. tacrolimus
    • o immunosuppressant
    • o calcineurin inhibitor by binding FKBP-12, downregulates IL-2
  11. 11. etanercept
    • o cytokine inhibitor, immunosuppressant, anti-RA
    • o anti-TNF-alpha
  12. 12. infliximab
    • o cytokine inhibitor, immunosuppressant, anti-RA
    • o chimeric IgG1, anti-TNF-alpha
  13. 13. Ustekinumab
    • o cytokine inhibitor, immunosuppressant
    • o Inhibitor of IL-12 and IL-23, binds p40
  14. 14. antithymocyte globulin (ATG)
    • o Immune cell depleter
    • o Antibodies bind CD2/3/4/8/11a/18/25/44/45, HLA class 1 and 2 on T,B, NK cells
  15. 15. muromonab
    • o Immune cell depleter
    • o Anti-CD3 (OKT3)
    • o Internalization of TCR
  16. 16. rituximab
    • o Immune cell depleter, anti-RA
    • o Anti-CD20, depletes mature B-cells
  17. 17. daclizumab
    • o Immune cell depleter
    • o Anti-CD25 (Anti-IL-2R),
    • o humanized IgG1
  18. 18. basiliximab
    • o Immune cell depleter
    • o Anti-CD25 (Anti-IL-2R)
    • o chimeric IgG1
  19. 19. alemtuzumab
    • o Immune cell depleter
    • o Anti-CD52
  20. 20. alefacept
    • o Immune cell depleter
    • o binds CD2, inhibiting LFA-3/CD2 interaction
  21. 21. abatacept
    • o inhibitor of costimulation
    • o CTLA-4/IgG1
    • o binds CD80 and CD86 (B7) on APC
  22. 22. belatacept
    • o inhibitor of costimulation
    • o CTLA-4/IgG1
    • o binds CD80 and CD86 (B7) on APC
  23. 23. Levamisole
    • o Immunostimulant
    • o �Restore" depressed immune function of B- & T-lymphocytes, monocytes, and macrophages
  24. 24. thalidomide
    • o Immunostimulant
    • o Inhibits TNFa synthesis
    • o Inhibits basic fibroblast growth factor (bFGF)-induced angiogenesis
  25. 25. Bacillus Calmette-Gu�rin (BCG)
    • o Immunostimulant
    • o induces a granulomatous reaction against tumors
  26. 26. IFNa-2b (intron A)
    • o Immunostimulant
    • o proteins in response to viral infection
  27. 27. avonex
    • o IFNb-1a
    • o antiviral/immunomodulatory
    • o MOA unclear
  28. 28. betaseron
    • o IFNb-1b
    • o antiviral/immunomodulatory
    • o MOA unclear
  29. 29. actimmune
    • o immunomodulator
    • o IFN-gamma-1b
    • o activates phagocytes, generation of oxygen metabolites
  30. 30. Aldesleukin
    • o Immunostimulator
    • o human recombinant IL-2
  31. 31. intravenous immunoglobulin (IVIG)
    • o immunostimulator
    • o Modulation of expression and function of Fc
    • o receptors
  32. 32. epoietin alfa
    • o anti-anemic
    • o recombinant human EPO
    • o binds JAK2 associated receptor
  33. 33. darbapoietin alfa
    • o anti-anemic
    • o recombinant human EPO
    • o binds JAK2 associated receptor
    • o (longer half life)
  34. 34. deferoxamine
    • o iron toxicity antidote
    • o Fe chelator
  35. 35. ferrous sulfate
    • o anti-anemic
    • o oral Fe 2+
    • o iron supplement
  36. 36. iron dextran
    • o anti-anemic
    • o parenteral iron supplement
    • o macrophage dependent
  37. 37. Na+ ferric gluconate
    • o anti-anemic
    • o parenteral iron supplement
    • o preferred agent, 80% to transferrin
  38. 38. iron sucrose
    • o anti-anemic
    • o parenteral iron supplement
  39. 39. pteroylglutamic acid
    • o anti-anemic
    • o folic acid supplement
  40. 40. mecasermin
    recombinant human IGF-1
  41. 41. lanreotide
    • o somatostatin analog
    • o inhibits GH
  42. 42. octreotide
    • o somatostatin analog
    • o inhibits GH
  43. 43. pasireotide
    • o somatostatin analog
    • o inhibits GH
  44. 44. pegvisomant
    GHR antagonist
  45. 45. cabergoline
    • o dopamine agonist
    • o suppress prolactin secretion
  46. 46. bromocryptine
    • o dopamine agonist
    • o suppress prolactin secretion
  47. 47. gonadorelin
    GnRH agonist
  48. 48. goserelin
    GnRH agonist
  49. 49. leuprolide depot
    GnRH agonist
  50. 50. ganirelix
    GnRH ant-agonist
  51. 51. cetrorelix
    GnRH ant-agonist
  52. 52. menotropins
    impure FSH and LH
  53. 53. urofollitropin
    uFSH with monoclonal antibodies
  54. 54. follitropin-alpha or beta
    rFSH
  55. 55. choriogonadotropin alpha
    rhCG
  56. 56. Novarel, Pregnyl, Profasi
    urine derived hCG
  57. 57. lutropin alpha
    rLH
  58. 58. Atosiban
    • o oxytocin antagonist
    • o tocolytic
  59. 59. levothyroxine sodium
    T4 hormone
  60. 60. liothyronine sodium
    T3 hormone
  61. 61. liotrix
    combo T3 and T4
  62. 62. propylthiouracil
    • o thioamide
    • o anti-thyroid, binds thyroglobulin peroxidase
  63. 63. methimazole
    • o thioamide
    • o anti-thyroid, binds thyroglobulin peroxidase
  64. 64. carbimazole
    • o thioamide
    • o anti-thyroid, binds thyroglobulin peroxidase
  65. 65. perchlorate
    • o ClO4-
    • o anionic inhibitor
    • o anti-thyroid agent
    • o inhibit Na/I symporter
  66. 66. fluoroborate
    • o BF4-
    • o anionic inhibitor
    • o anti-thyroid agent
    • o inhibit Na/I symporter
  67. 67. pertechnate
    • o TcO4-
    • o anionic inhibitor
    • o anti-thyroid agent
    • o inhibit Na/I symporter
  68. 68. iodide
    • o anti-thyroid
    • o high amounts inhibit hormone release
  69. 69. Lithium
    • o anti-thyroid adjuvant
    • o inhibits release of thyroid hormone
  70. 70. amiodarone
    • o anti-thyroid adjuvant
    • o blocks T4--> T3 conversion, blocks T3 binding, blocks iodide organification
  71. 71. propranolol
    • o anti-thyroid adjuvant
    • o treats sympathetic effects of thyrotoxicosis
  72. 72. mifepristone
    • o Anti-adrenocorticosteroid
    • o blocks progesterone receptor
    • o competes with progesterone and GC
    • o for Cushings
  73. 73. fondaparinux
    LMW heparin
  74. 74. protamine sulfate
    bleeding antidote
  75. 75. lepirudin
    • o non-heparin parenteral
    • o direct thrombin inhibitor
  76. 76. bivalirudin
    • o non-heparin parenteral
    • o direct thrombin inhibitor
  77. 77. argatroban
    • o non-heparin parenteral
    • o thrombin inhibitor
  78. 78. drotrecogin alfa
    • o non-heparin parenteral
    • o serine protease/protein C
  79. 79. warfin
    • o oral anticoagulant
    • o Antagonist of vitamin K-dependent synthesis of coagulation factors II, VII, IX and X
  80. 80. dabigatran etexilate
    • o oral anticoagulant
    • o reversibly blocks the active site of thrombin
  81. 81. aspirin
    • o antiplatelet
    • o COX-1 inhibitor
  82. 82. ticlopidine
    • o antiplatelet
    • o purinergic receptor antagonist
    • o blocks the P2Y12 receptor
  83. 83. clopidogrel
    • o anti-platelet
    • o purine receptor antagonist
    • o blocks P2Y12 receptor
  84. 84. abciximab
    • o antiplatelet
    • o GP 2b/3a antagonist
  85. 85. eptifibatide
    • o antiplatelet
    • o GP 2b/3a antagonist
  86. 86. tirofiban
    • o antiplatelet
    • o GP 2b/3a antagonist
  87. 87. streptokinase
    • o fibrinolytic
    • o binds plasminogen noncovalently, exposing for cleavage
  88. 88. alteplase
    • o fibrinolytic
    • o recombinant tPA
  89. 89. reteplase
    • o fibrinolytic
    • o recombinant tPA (longer t1/2)
  90. 90. Tamoxifen
    • o antiestrogen --SERM
    • o decrease proliferation of ER+ breast cancer cells
  91. 91. clomiphene
    • o estrogen antagonist
    • o increases FSH, induce ovulation
  92. 92. fulvestrant
    • o pure anti-estrogen
    • o for tamoxifen resistant breast cancer
  93. 93. exemestane
    • o type 1 anti-aromatase
    • o non-competetive suicide inhibitors
  94. 94. letrozole
    • o anti-aromatase
    • o reversible, binds CYP heme moiety
  95. 95. anatrozole
    • o anti-aromatase
    • o reversible, binds CYP heme moiety
  96. 96. premarin
    • o estrogen
    • o oral mixture of equine sulfates of estrone
  97. 97. norgestrel
    • o progesterone only contraceptive
    • o 75 ug
  98. 98. medroxyprogesterone acetate
    • o pregnane progestin
    • o for menopausal HT
  99. 99. norethindrone
    • o estrane progestin
    • o for progesterone only contraception
  100. 100. norgestimate
    • o gonane progestin
    • o for contraception
  101. 101. levonorgestrel
    gonane progestin
  102. 102. finasteride
    • o 5-alpha reductase inhibitor
    • o inhibitor at type 2, blocks DHT formation
  103. 103. dutasteride
    • o 5-alpha reductase inhibitor
    • o inhibitor at type 1 and 2, blocks DHT formation
  104. 104. flutamide
    • o androgen receptor antagonist
    • o blocks testosterone effects
  105. 105. bicalutamide
    • o androgen receptor antagonist
    • o blocks testosterone effects
  106. 106. nilutamide
    • o androgen receptor antagonist
    • o blocks testosterone effects
  107. 107. calcitriol
    vitamin D3
  108. 108. ergocalciferol, dihydrotachysterol
    • o vitamin D2
    • o for hypoparathyroidism
  109. 109. doxercalciferol, paricalcitol
    vitamin D2
  110. 110. cinacalcet
    • o type 1 calcimimetic
    • o full agonist, enhances CaSR sensitivity
  111. 111. phenylalkylamine
    • o Type 2 calcimimetic
    • o allosteric CaSR modulators, requires calcium
  112. 112. lanthanum
    phosphate binder to decrease its absorption
  113. 113. sevelamer
    phosphate binder to decrease its absorption
  114. 114. raloxifene
    • o SERM
    • o agonist in bone (antiresorptive), antagonist in breast and endometrium
  115. 115. salmon calcitonin
    anti-resorptive
  116. 116. denosumab
    • o human RANKL mAb IgG2
    • o prevent RANKL--RANK binding on osteoclasts
  117. 117. alendronate
    • o 2nd generation bisphosphonate
    • o inhibit FPPS
  118. 118. ibandronate
    • o 2nd generation bisphosphonate
    • o inhibit FPPS
  119. 119. risedronate
    • o 3rd generation bisphosphonate
    • o inhibit FPPS
  120. 120. zoledronate
    • o 3rd generation bisphosphonate
    • o inhibit FPPS
  121. 121. glucosamine
    • o anti-OA
    • o stimulates synthesis of proteoglycans
  122. 122. chondroitin
    • o anti-OA
    • o supposed chondroprotective, anti-inflammatory and analgesic effects
  123. 123. synvisc (hyaluronic acid)
    • o anti-OA
    • o Improves viscosity/elastic properties of synovial fluid
  124. 124. BMP-7
    • o anti-OA
    • o stimulates collagen proteoglycan and hyaluronic acid synthesis; slows cartilage breakdown by inhibiting IL-1
  125. 125. FGF-18
    • o anti-OA
    • o Coordinates chondrocyte and osteoblast growth and differentiation
  126. 126. Pralnacasan and AMG-108
    • o anti-OA
    • o IL-1 inhibitors
    • o NOT effective
  127. 127. tanezumab
    • o anti-OA
    • o humanized IgG2 monoclonal AB against NGF
  128. 128. sulfasalazine/mesalamine
    • o anti-RA, DMARD
    • o increase folate, decrease IL-1/NFkB, decrease ROS
  129. 129. hydroxychloroquine
    • o anti-RA, DMARD
    • o acidic pH in cell lysosomes
  130. 130. leflunomide
    • o anti-RA, DMARD
    • o dihydroorotate dehydrogenase inhibitor
  131. 131. adalimumab
    • o biologic anti-RA
    • o fully human recombinant IgG1 anti-TNF? mAb
  132. 132. golimumab
    • o biologic anti-RA
    • o fully human recombinant IgG1 anti-TNF? mAb
  133. 133. certolizumab pegol
    • o biologic anti-RA
    • o humanized PEGprotein; murine anti-TNF? Ab in variable domains
  134. 134. anakinra
    • o biologic anti-RA
    • o fully humanized recombinant IL-1 receptor antagonist
  135. 135. abatacept
    • o biologic anti-RA
    • o CTLA-4 binding region fused to human IgG1 Fc
  136. 136. tocilizumab
    • o biologic anti-RA
    • o fully humanized mAb/ IL-6 receptor antagonist
  137. 137. indomethacin, sulindac, naproxen, celecoxib
    • o anti-gout agents
    • o NSAIDS
  138. 138. allopurinol
    • o anti-gout agent
    • o xanthine oxidase inhibitor
  139. 139. febuxostat
    • o anti-gout agent
    • o xanthine oxidase inhibitor
  140. 140. probenacid
    • o anti-gout agent
    • o Inhibits URAT-1; increases uric acid excretion
  141. 141. colchicine
    • o acute gout relief, second line
    • o blocks microtubule formation
  142. 142. rasburicase
    • o anti-gout agent
    • o recombinant urate oxidase inhibitor
  143. 143. pegloticase
    • o anti-gout agent
    • o pegylated recombinant urate oxidase inhibitor

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