Clinical Chemistry

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Author:
Choyte02
ID:
147133
Filename:
Clinical Chemistry
Updated:
2012-04-11 22:44:09
Tags:
Enzymes
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Description:
Enzymes
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  1. Specific biologic proteins that catalyze biochemical reaction without altering the equilibrium point of the reaction or being consumed or changed in composition.
    Enzyme
  2. An organic cofactor, such as nicotinamide adenine dinucleotide.
    Coenzyme
  3. Catalyze an oxidation-reduction reaction between two substrates.
    Oxidoreductase
  4. Catalyze the transfer of a group other than hydrogen from one substrate to another.
    Transferase
  5. Catalyse hydrolysis of various bonds.
    Hydrolases
  6. Catalyze removal of groups from substrates without hydrolysis; the product contains double bonds.
    Lyases
  7. Catalyze the interconversion of geometric, optical, or posistional isomers.
    Isomerase
  8. Catalyze the joining of two substrate molecules, coupled with breaking of the pyrophosphate bong in adenosine triphosphate (ATP) or a similar compound.
    Lipase
  9. Excess energy required to raise all molecules in 1 mole of a compound at a certain temperature to the transition state at the peak of the energy barrier.
    Activation energy
  10. What is the equation that depicts the relationship between the enzyme, substrate, and product?
    E + S K ES K E + P
  11. Clinical Significance:
    Acid phosphatase (ACP)
    Prostatic carcinoma
  12. Clinical Significance:
    Alanine aminotransferase (ALT)
    Hepatic disorder
  13. Clinical Significance:
    Alkaline phosphatase (ALP)
    • Hepatic disorder
    • Bone disorder
  14. Clinical Significance:
    Amylase (AMS)
    Acute Pancreatitis
  15. Clinical Significance:
    Aspartate amino-transferase (AST)
    • Myocardial infarction
    • Hepatic disorder
    • Skeletal muscle disorder
  16. Clinical Significance:
    Creatine Kinase (CK)
    • Myocardial infarction
    • Skeletal muscle disorder
  17. Clinical Significance:
    Gluclose-6-phosphate dehydrogenase (G-6-PD)
    Drug induced hemolytic anemia
  18. Clinical Significance:
    gamma-glutamyltransferase (GGT)
    Hepatic disorder
  19. Clinical significance:
    Lactate dehydrogenase (LDH)
    • Myocardial infarction
    • Hepatic disorder
    • Hemolysis
    • Carcinoma
  20. Clinical Significance:
    Lipase (LPS)
    Acute pancreatitis
  21. Clinical Significance:
    Pyruvate kinase (PK)
    Hemolytic anemia
  22. What is are the three designations of the isoenzymes?
    • CK-MM (muscle type)
    • CK-MB (hybrid type)
    • CK-BB (brain type)

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