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Potent diuretic with a rapid rate of onset and short duration action.
Mechanism of Action
- Loop diuretic that inhibits the reabsorption of NaCl in kidneys thus causing a net diuresis.
- 1mg Bumetanide = 40mg furosemide
Onset of Action
- Onset: 1-2 min
- Peak: 15-30 min
- Duration: 3.5-4 hrs
- Half-life: 60-90 min
Adjunct to nitro and ACE inhibitors in CHF & pulmonary edema
Only use in severe emergency with pregnant pts
- Dehydration & electrolyte depletion in excessive doses
- If pt allergic to furosemide usually NOT allergic to Bumetanide
- Muscle cramps
Route of Administration
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