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  1. HIV
    • Human Immunodeficiency Virus
    • Everyone with AIDS is HIV+
    • Not everyone with HIV has AIDS
  2. Origin of HIV Infection
    From Africa in the 50's
  3. How HIV Spread
    • SIV mutated and picked up a new host
    • SIV from monkey, monkey eaten raw, virus not killed, and transferred to humans
    • Doctors treated people with this disease with one needle, and used same needle on multiple people
  4. 2 Types of HIV Infections
    • HIV-1
    • HIV-2
  5. HIV-1
    • Group N
    • Group M: Clades A-J
    • Group O
    • Comes from chimpanzees
    • Mutated to humans in the 30's
  6. HIV-2
    • Comes from the Scooty Mangaby
    • No symptoms
    • Having HIV-2 can help prevent getting HIV-1
  7. HIV Structure
    • RNA (2 strands)
    • Enzymes (Reverse transcriptase: reverse transcription from RNA to DNA; Integrase, Protease)
    • Protein coat
    • Envelope with GP spikes
  8. HIV Looking for a Home
    HIV targets Langerhan cells, macrophages, dendritic cells, and CD4 positive T cells
  9. Helper T Cell Review
    • Helper T-lymphocyte recognizes antigen
    • Helper T-lymphocyte secretes cytokines and begins to undergo cell division to form more helper T-lymphocyte
    • Cytokines secreted by helper T-lymphocytes initiate and control the immune system
  10. Acute Phase
    • Fever
    • Fatigue
    • Sore Throat
    • Muscle aches
    • Headache +/-
    • Swollen Lymphnodes
    • +/- nausea/loss of appeite
  11. Chronic/Latent Phase
    Looks normal
  12. AIDS Phase
    Opportunistic infections and cancers occur
  13. HIV Transmission
    • Blood
    • Semen
    • Vaginal Fluid
    • Breast Milk
    • Blood Products
  14. HIV Testing
    Oral test ? looking for the antibody-coated
  15. How to prevent early death of an HIV infected person
    • Keep stress down
    • Healthy diet
    • Sleep normal amount
    • Vitamins
    • Invert reverse transcription
  16. Treatment
    • Fusion/entry Inhibitors
    • Reverse Transcriptase Inhibitors (prevent reverse transcripse) (EZT?)
    • Integrase Inhibitors
    • Protease Inhibitors
  17. Drug Therapy For HIV Infections
    • HAART
    • Highly Active
    • Anti-Retroviral
    • Therapy

Card Set Information

2012-04-16 22:19:41

bio 205
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