MED-Epinephrine

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Author:
amerelman
ID:
14804
Filename:
MED-Epinephrine
Updated:
2010-04-16 10:21:52
Tags:
MED Epinephrine
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Description:
MED-Epinephrine
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  1. Functional Class
    Sympathomimetic
  2. How it is supplied
    • 1:1000 - 1mg/ml
    • 1:10,000 - 0.1mg/ml
  3. Mechanism of Action
    Naturally occuring catecholamine. Acts directly on alpha and beta (primarily) adrenergic receptors. Causes positive inotropic, chronotrpic and dromotropic effects as well as increased vascular resistance in BP.
  4. Indications
    • Cardiac Arrest (Asystole, VF, Pulseless VT, PEA)
    • Symptomatic bradycardia
    • Anaphylaxis
    • Severe reactive airway disease
  5. Contraindications
    Hypersensitivity to sympathomimetic amines
  6. Precautions
    • Protect from light
    • Can be deactivated by sodium bicarbonate. Flush IV between using epi and bicarb
    • Effects intensified by anti-depressants
  7. Side Effects
    • Increases myocardial oxygen demand
    • Palpitations
    • Anxiety
    • Headache
    • CVA
    • Syncope
    • HTN
    • Tachydysrhythmias
    • Tissue necrosis with repeated injections or extravasation of IV
  8. Drug Interactions
    • May increase hypotension caused by phenotiazines, alpha and beta blockers
    • Can be deactivated in alkaline solutions or sodium bicarbonate
  9. Dosage and Route
    • Cardiac Arrest
    • ADULT
    • 1.0 mg 1:10,000 IVP q 3-5 mins
    • 2.0-2.5 mg 1:1,000 ET diluted to 10 mL q 3-5 mins

    • PEDI
    • 0.01 mg/kg 1:10,000 IV/IO
    • 0.1 mg/kg 1:1,000 ET diluted to 10 mL q 3-5 mins

    • Severe Anaphylaxis/Asthma
    • ADULT
    • 0.3-0.5 mg SQ 1:1,000 q 5-15 mins then if ineffective 0.1-0.5 mg IVP 1:10,000 q 5-15 mins

    • PEDI
    • 0.01 mg/kg 1:1,000 SQ then if ineffective 0.01 mg/kg IVP 1:10,000 q 5-15 mins

    • Symptomatic Bradycardia Infusion
    • 1 mg of 1:1000 in 250 mL NS

    • ADULT
    • 2-10 mcg/min

    • PEDI
    • 0.1-1 mcg/kg/min

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