Critical Thinking: Walk through how to figure out what the side effects of AMV antifungals are based on the MOA. Then work through the nursing implications. Keep in mind that Posaconazle is used b/c it has much fewer renal toxicities.
MOA = create holes/increase perm in membrane. This allows K+/Mg+ to escape and cell dies. The major side effects are renal, the electrolytes are lost due to a reversable decrease in GFR. Nursing indications say we need to flush the kideys with lots of H2O, monitor the BUN/Creatinine levles and then replace the electrolytes. The hard part is remembering that fever/chills can be side effects of this as well.