H-1 receptor antagonist; blocks action of histamine; possesses sedative, anti-motion, antiemetic and anticholinergic activity; potentiates the effects of narcotics to induce analgesia.
Nausea, vomiting, motion sickness; sedation for patients in labor; potentiation of analgesic effects of narcotics.
Hypersensitivity, coma, CNS-depressed patients from alcohol, barbiturates, narcotics, Reye's syndrome.
Sedation, dizziness, impairment of mental and physical ability, arrhythmias,nausea, vomiting, hyperexcitability; halucinations, convulsions, and sudden death when used in children.
Additive with other CNS depressants. Increased extrapyramidal effects with MAOIs.
25 and 50 mg/ml in 1-ml ampules and Tubex syringes.
Dosage and administration
Adult: 12.5-25mg IV, deep IM, PO, rectally.
Pediatric: (greater than 2 years old) 0.25-0.5 mg/kg dose IM.
Duration of action
Onset: IV: immediate.
Peak effect: 30-60 minutes
Duration: 4-6 hours.
Pregnancy safety: Category C. Use cautiously in patients with asthma, peptic ulcer disease and bone marrow suppression. Do not use in children with vomiting of unknown etiology. Avoid intra-arterial injection. IM injection is preferred route.