Promethazine

Card Set Information

Author:
cirby2
ID:
14857
Filename:
Promethazine
Updated:
2010-04-16 19:31:16
Tags:
Pharmacology
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Description:
Phenergan
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  1. Class
    Antihistamine
  2. Mechanism of action
    H-1 receptor antagonist; blocks action of histamine; possesses sedative, anti-motion, antiemetic and anticholinergic activity; potentiates the effects of narcotics to induce analgesia.
  3. Indications
    Nausea, vomiting, motion sickness; sedation for patients in labor; potentiation of analgesic effects of narcotics.
  4. Contraindications
    Hypersensitivity, coma, CNS-depressed patients from alcohol, barbiturates, narcotics, Reye's syndrome.
  5. Adverse reactions
    Sedation, dizziness, impairment of mental and physical ability, arrhythmias,nausea, vomiting, hyperexcitability; halucinations, convulsions, and sudden death when used in children.
  6. Drug interactions
    Additive with other CNS depressants. Increased extrapyramidal effects with MAOIs.
  7. How supplied
    25 and 50 mg/ml in 1-ml ampules and Tubex syringes.
  8. Dosage and administration
    • Adult: 12.5-25mg IV, deep IM, PO, rectally.
    • Pediatric: (greater than 2 years old) 0.25-0.5 mg/kg dose IM.
  9. Duration of action
    • Onset: IV: immediate.
    • Peak effect: 30-60 minutes
    • Duration: 4-6 hours.
  10. Special considerations
    Pregnancy safety: Category C. Use cautiously in patients with asthma, peptic ulcer disease and bone marrow suppression. Do not use in children with vomiting of unknown etiology. Avoid intra-arterial injection. IM injection is preferred route.

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