What is the major class of insulin sensitizers? What do they bind to get the effect? Name the three drugs with the current status.
- Class: Thiazolidinedione PPAR agonist
- Peroxisone Proliferator-Activated Receptor-gama (PPARy) which are nuclear transcription factors
- Troglitazone- withdrawn due to severe liver toxicity
- Rosiglitazone- Restricted use by FDA
- Pioglitazone- Black Box Warning (Avandia)