abio Cancer

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  1. Cancer cells must:
    • proliferate
    • invade
    • mestasize
  2. Epidemiology:
    • identifies preventable causes
    • (prevention is better than cure)
  3. Mutation:
    permanent change in a cell's DNA; includes changes in nucleotide seq., alteration of gene position, gene loss or duplication, and insertion of foreign seq.
  4. Dominant vs Recessive mutation:
    • dominant: gain of function
    • recessive: loss of function
    • Image Upload 1
  5. Cancer:
    the unrestrained growth and division of cells, reults in failure of cell division control.
  6. Oncogene:
    a mutant form of a growth regulating gene that is inappropriately 'ON' , causing unrestrained cell growth and division.
  7. Proto-oncogene
    a normal cellular gene that can act as an oncogene when mutated.
  8. Tumor:
    neoplasm [a solid or fluid-filled (cystic) lesion that may or may not be formed by an abnormal growth of neoplastic cells] that appears enlarged in size
  9. Metastasis:
    migration of cancerous cells
  10. benign vs cancerous tumor
    • benign tumor:lacks ability to metastyze (moles)
    • canceroues - migrates
  11. Carcinogens:
    A carcinogen is any substance, radionuclide, or radiation that is an agent directly involved in causing cancer.
  12. Mutagens:
    • is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations
    • As many mutations cause cancer, mutagens are therefore also likely to be carcinogens.
  13. Tumor suppressors:
    or anti-oncogene, is a gene that protects a cell from one step on the path to cancer.
  14. Genetic changes convert proto-oncogene into an oncogene:
    Image Upload 2
  15. Cancer progression:
    Image Upload 3
Card Set
abio Cancer
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