Antiparasitic 2

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  1. Name the parasite that causes heartworm disease in dogs and cats.
    Dirofilaria immitis
  2. List the 3 stages of heartworm therapy.
    • adulticide therapy
    • microfilaricide therapy
    • preventative therapy
  3. Who gets heartworm therapy - dogs, cats, or both? Explain.
    • dogs only
    • at this time, treatment of heartworm positive cats is controversial and not generally done. no adulticides are approved for use in cats
  4. Why is it better to kill off adult heartworms gradually instead of all at once?
    to minimize the inflamatory reaction as they die off and become lodged in the lungs.
  5. Why should exercise be restricted after heartworm adulticide therapy?
    to keep too many pieces of dead worms from breaking loose and going to the lungs at once.
  6. List 2 adulticide drugs. Which is now in use, and which is obsolete?
    • melarsomine - Immiticide - in use
    • thiacetarsemide - Caparsolate - obsolete
  7. In general, what type of compound is melarsomine - Immiticide?
  8. Does melarsomine have a wide or a narrow margin of safety?
    narrow - effective dosage is close to toxic dosage
  9. How is melarsomine administered?
    deep IM injection in lumbar muscles
  10. What drug is antidotal to melarsomine?
    dimercaprol - BAL
  11. How soon after adulticide therapy is microfilaricide therapy usually administered?
    3 - 4 weeks
  12. List 4 reasons to kill circulating microfilaria.
    • source of infection for other dogs.
    • cause certain heartworm tests to show false positives
    • can cause reactions if patient is treated with certaind drugs
    • microfilaria can physically interfere with capillary blood flow.
  13. List 3 drugs that can or have been used for microfilaricide therapy.
    • milbemycin
    • levamisole
    • ivermectin
  14. Are any of these drugs approved for this purpose?
  15. Which one is most commonly used?
  16. List 5 drugs that have been or are used as heartworm preventatives.
    • ivermectin - Heartgard
    • milbemycin - Interceptor
    • selamectin - Revolution
    • moxidectin - Advantage Multi
    • diethylcarbamazine - Filaribits
  17. Which of these are macrolides?
    • ivermectin
    • milbemycin
    • selamectin
    • moxidectin
  18. Which of these is pretty much obsolete?
  19. Which of these are given PO once a month?
    • ivermectin - Heartgard
    • milbemycin - Interceptor
  20. Which of these is given topically once a month?
    • selamectin - Revolution
    • moxidectin - Advantage Multi
  21. Which of these are given orally once a day?
    diethylcarbamazine - Filaribits
Card Set
Antiparasitic 2
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