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What makes up in innate immune system?
marcrophages, NK cells
If allergic to peanut, chances will be allergic to another nut?
Deficiency in hereditary angioedema?
C1 esterase inhibitor
How is ataxia telangiectasia inherited?
autosomal recessive (ch 11)
Which immune deficiency is correlated with anaphylaxis to blood products?
Are the levels high or low for each of the following in Wiskott-Aldrich syndrome? IgA, IgE, IgM
How is C1 inhibitor deficiency inherited?
Can you give live vaccines to household children where an immune deficient patient lives?
- Yes, delay varicella in SCID sibling until transplanted
- AND, use inactivated flu for contacts (and health care) for people in contact with immunodeficient patients
When histamine reacts with the H1 receptor, what happens? H2? H3?
- H1: wheal and flare, bronchoconstriction, and pruritus
- H2: increased gastric acid
- H3: decreased histamine synthesis
What type of hypersensitivity reaction is Myasthenia gravis?
What type of hypersensitivity reaction is autoimmune hemolytic anemia?
Explain Type I hypersensitivity.
IgE ab binds to receptor on mast cells
**Late response- 3-12 hours later
Explain Type II hypersensitivity.
IgG ab binds to a fixed tissue antigen or cell receptor (autoantibodies)
Explain Type III hypersensitivity.
immune complexes form when ab combine with antigen
**Any time you see vasculitis think type III!!
Explain Type IV hypersensitivity.
previously sensitized T cells interact with antigen causing inflammatory reaction ( delayed type hypersensitivity)
Most common manifestations of anaphylaxis?
angioedema and urticaria
Dose and max dose for epi when giving for anaphylaxis?
0.01mg/kg to a max of .5mg
What are the two major and three minor criteria of the asthma redictive index?
- Major: parent with asthma, physician-diagnosed eczema
- Minor: dr-diagnosed AR, wheezing apart from URI, eosinophilia
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