Card Set Information

2012-05-06 15:32:13
allergy immunology

A/I questions
Show Answers:

  1. What makes up in innate immune system?
    marcrophages, NK cells
  2. If allergic to peanut, chances will be allergic to another nut?
  3. Deficiency in hereditary angioedema?
    C1 esterase inhibitor
  4. How is ataxia telangiectasia inherited?
    autosomal recessive (ch 11)
  5. Which immune deficiency is correlated with anaphylaxis to blood products?
    IgA deficiency
  6. Are the levels high or low for each of the following in Wiskott-Aldrich syndrome? IgA, IgE, IgM
    • high- IgA, IgE
    • low- IgM
  7. How is C1 inhibitor deficiency inherited?
  8. Can you give live vaccines to household children where an immune deficient patient lives?
    • Yes, delay varicella in SCID sibling until transplanted
    • AND, use inactivated flu for contacts (and health care) for people in contact with immunodeficient patients
  9. When histamine reacts with the H1 receptor, what happens? H2? H3?
    • H1: wheal and flare, bronchoconstriction, and pruritus
    • H2: increased gastric acid
    • H3: decreased histamine synthesis
  10. What type of hypersensitivity reaction is Myasthenia gravis?
    Type II
  11. What type of hypersensitivity reaction is autoimmune hemolytic anemia?
    Type II
  12. Explain Type I hypersensitivity.
    IgE ab binds to receptor on mast cells

    **Late response- 3-12 hours later
  13. Explain Type II hypersensitivity.
    IgG ab binds to a fixed tissue antigen or cell receptor (autoantibodies)
  14. Explain Type III hypersensitivity.
    immune complexes form when ab combine with antigen

    **Any time you see vasculitis think type III!!
  15. Explain Type IV hypersensitivity.
    previously sensitized T cells interact with antigen causing inflammatory reaction ( delayed type hypersensitivity)
  16. Most common manifestations of anaphylaxis?
    angioedema and urticaria
  17. Dose and max dose for epi when giving for anaphylaxis?
    0.01mg/kg to a max of .5mg
  18. What are the two major and three minor criteria of the asthma redictive index?
    • Major: parent with asthma, physician-diagnosed eczema
    • Minor: dr-diagnosed AR, wheezing apart from URI, eosinophilia