MS2_PHARM_adren_rec_FINAL.txt

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Author:
soren101
ID:
149735
Filename:
MS2_PHARM_adren_rec_FINAL.txt
Updated:
2012-04-24 00:29:17
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Description:
pharmacology adrenergic receptor actions ms2
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  1. a1-ADRENORECEPTORS FOUND IN:
    • POSTJUNCTIONAL SITES:
    • EFFECTOR ORGANS, TISSUES AND GLANDS INNERVATED BY SYMP NERVES

    INC INTRACELLULAR INH OF ADEN CYCL --> DEC cAMP

    SIGNAL BY IP3 & DAG
  2. a2 - ADRENORECEPTORS FOUND AT
    • 1. POSTJUNCTIONAL SITES:
    • EFFECTOR ORGANS, TISSUES AND GLANDS INNERVATED BY SYMP NERVES

    INC INTRACELLULAR INH OF ADEN CYCL --> DEC cAMPIP3 & DAG

    • 2. PREJUCTIONAL SITES:
    • SYMP NEURONS (AUTO --> Gi INC K)

    PARASYMP NEURONS OF SA, SPHINC OF IRIS, GI, (HETERO --> Gi INC K)
  3. b1-ADRENORECEPTORS FOUND AT
    • POSTJUNCIONAL SITES:
    • CARDIAC MUSCLES

    CARDIAC CONDUCTION TISSUE

    ADIPOCYTES

    JG CELLS OF RENAL AFFERENT ARTERIOL
  4. b2-ADRENORECEPTORS FOUND AT
    • POSTJUNTIONAL SITES:
    • ARTERIOLS AND VENULES

    BRONCHIOLS

    UTERUS

    GI

    LIVER

    • PREJUNCTIONAL SITES:
    • SYMP NEURONS (HETERO)
  5. SYMP MUSCLES OF EYE
    RADIAL, IRIS -- a1

    SMOOTH MUSC OF EYELID --a?

    CANAL OF SCHLEMM -- NOT INERVATED BUT:

    • a1 -- ENHANCED OUTFLOW
    • a2 -- DEC PROD
  6. DISTRIBUTION OF a AND b2 IN ARTERIOL BEDS
    b2 PREDOMINATE IN SKEL MUSC

    a PREDOMINATE IN GI AND KIDNEY
  7. EPI, NE, AND PE SELECTIVITY
    • EPI -- b2 > b1 > a
    • NE -- a > b1 > b2
    • PE -- a1 ONLY

    PE = PHENYLEPHRINE
  8. a1 RECEPTOR: LOCATIONS AND ACTION
    • Arterioles
    • constriction

    • Eye
    • enhanced normal
    • outflow of canal of schlemm


    • Eye
    • radial muscle
    • contraction of iris (dilation, mydriasis)


    • Kidney
    • proximal tubule
    • increased sodium/water reabsorption


    • Lung
    • bronchial gland
    • secretion decrease


    • Salivary Glands
    • water and K+ secretion (viscous and sticky)


    • Skin
    • pilomotor muscle
    • contraction


    • Urethra
    • contraction


    • Venules
    • constriction

    • --a1a--
    • Male Sex Organs
    • vas deferens, ampulla, prostate gland and seminal vesicles emission and ejaculation


    • Urinary Tract
    • trigone and ext. sphincter
    • contraction
  9. a2 RECEPTOR: LOCATIONS AND ACTION
    • Arterioles
    • constriction
  10. Eye
    decreased production of aq fluid in eye
  11. Pancreas
    • islet (B) cells
    • (insulin) decreased secretion
  12. Platelets
    aggregation
  13. Stomach and Intestines
    motility and tone decreased
  14. Stomach and Intestines
    secretion is inhibited
  15. Venules
    constriction
  16. b2 RECEPTOR: LOCATIONS AND ACTION
    • Arterioles
    • dilation (via circulating Epi)
  17. Gallbladder and ducts
    relaxation
  18. Liver
    glycogenolysis and gluconeogenesis increase
  19. Lung
    • bronchial muscle
    • relaxation
  20. Skeletal Muscle
    glycogenolysis, K+ uptake, tremor, and increased contractility
  21. Uterus
    relaxation for pregnant and nonpregnant women
  22. Venules
    dilation (via circulating Epi)

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