Opioid Pharmacology

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Author:
jheneale
ID:
14994
Filename:
Opioid Pharmacology
Updated:
2010-04-18 00:04:34
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Nrs
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Nrs Interventions
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  1. Mild to Moderate Pain Opiates (3)
    • (Codeine, Oxycodone, Hydrocodone)
    • - prescribe w/ a non-opioid (reduce the dose of opioids and produce more analgesic)
    • - Ex: Tylanol #3, Vicodin
  2. Ultram (2) S.E (4)
    • - Roughly the same efficiacy as Tylenol #3
    • - No tolerance, physical dependency, or addiction
    • - S.E= Nausea, Constipation, Dizziness, Sedation
  3. Opioids (2)
    (10) drugs
    • - controlled substances
    • - has NO analgesic ceiling, can be administered several routes
    • - Morphine, Fentalyn, Diludad, Percocet
    • -Demerol, Methadone
    • - Avinza, Duramorph, MS contin, Roxanol
  4. Opioiods for Long acting Chronic pain ATC relief for extended time (4)
    • 1. Avinza
    • 2. Duramorph
    • 3. MS Contin
    • 4. Roxanol
  5. Demerol (4)
    Causes (3)
    • - severe pain
    • - limited by HIGH INCIDENCE OF SEIZURES
    • - Contraindicated for pts ACUTE PAIN +3 dAYS or who needs LARGER DOSES
    • -" pts taking MAO inhibitors
    • - Causes Hyperpyrexia , delirium, Death
  6. Opiates Most common side effects (5)
    At risk (3)
    • - Constipation
    • - nausea
    • - Vomitting
    • - Respiratory depression
    • - Pruritus
    • - AT RISK PTS Opioid Naive, Elderly, Lung Disease
  7. Less Common side effects Opiates (6)
    • - Urinary Retention
    • - Myoclonus
    • - Dizziness
    • - Confusion
    • - Hallucinations
    • * Physical Dependence
  8. Adjuvant drugs (1)
    (3) mechanisms
    • - Enhance the effects of the opioids provide additional pain relief
    • - Three mechanisms:
    • 1. Enhance effects of oipiods and non-opioids
    • 2. Possess anelgesic properties
    • 3. Counter act the side effects of other drugs
  9. Anticonvulsant (3)
    (3) drugs + (2) s.e
    • - Affective for NUEROPATHIC PAIN and treatment of headaches
    • - Start with a LOW DOSE then increase SLOWLY
    • - Baseline Liver, Renal, and CBC needed
    • 1. Gabapentin (Neurontin) :ankle swelling, ataxia (< coordination)
    • 2. Tegretol
    • 3. Klonpin
  10. Antidepressants (1)
    (4) Drugs; (4) S.E
    • - used for nueropathic pain
    • 1. Amitirptyline (Elavil)
    • 2. Doxepin (Sinquan)
    • 3. Notriptyline (Pamelor)
    • 4. Imipramine (Tofranil PM)
    • S.E= dry mouth, urinary retention, sedation, orthostatic hypotention
  11. Costicosteriods (3)
    (2) Drugs
    (8) S.E
    • - used for ACUTE and CHRONIC CANCER PAIN
    • - pain secondary to SPINAL CORD COMPRESSION
    • - nueropathic pain syndromes
    • 1. Decadron
    • 2. Medrol
    • S.E= (high dosage and long term used): hypergylcemia, fluid retention, dyspepsia
    • GI bleeding, Impaired healing, muscle wasting, osteoporosis, susceptible to infections

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