quiz 10

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150079
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quiz 10
Updated:
2012-04-27 01:15:51
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med chem
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steroids
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  1. anti-fibrinolytic agent
    treatment of cyclic heavy menstrual bleeding
    synthetic lysine amino acid, preserves and stabilizes fibrin's matrix structure
    tanexamic acid - lysteda
  2. treats ovarian failure and male infertility
    increases pituitary output of gonadotropins
    clomiphene citrate - clomid, milophene, serophene
  3. Treats prepubertal cryptochidism
    ovulation stimulations
    chorionic gonadotropin - chorex5, profasi, pregnyl
  4. Treats final follicular maturation and
    ovulation induction
    chorionic gonadotropin alpha -ovidrel
  5. A polypeptide
    Treats endometriosis and central precocious puberty
    nasal solution
    nafarelin acetate - synarel
  6. A polypeptide
    Treats primary hypothalamic amenorrhea
    injection
    gonadorelin acetate - lutrepulse
  7. Treats central precocious puberty
    histrelin acetate - supprelin injection
  8. A polypeptide
    palliative treatment of advanced prostate cancer by decreasing testosterone levels to castrate concentration following the first week of use
    vantus implant
  9. recombinant form of human luteinizing hormone
    deficiency levels of luteinizing hormon <1.2 IU/liter
    overexpressed in chinese hampster ovary cell
    use in conjunction with the gonadotropin product follitropin alpha - gonal F
    lutropin alfa for injection - luveris
  10. Treats advanced prostrate cancer to achieve medical castration
    sever bone pain from metastic disease
    It is a blocker of gonadotropin releasing hormone
    have to sign up with praecis pharmaceutical program
    QT elongation is a concern
    abarelix - plenaxis
  11. testosterone is metabolized to what primarily
    • 5 alpha dihydrotestosterone
    • necessary for maintaining proper prostate function in men
  12. inactive compound of testosterone
    17-ketone
  13. anabolics are contraindicated in who
    men with familial history of prostatic or testicular cancer.
  14. androgens and anabolic agents are what schedule
    3
  15. major concern of anaboic steroid use
    liver disease
  16. short acting testosterone product
    aqueous suspension
    tesamone
  17. short acting testosterone product
    SC pellets
    testopel
  18. short acting testosterone product
    transdermal
    testoderm, androderm
  19. short acting testosterone product
    buccal mucoadhesive
    adheres to the gum tissue above the incisors
    striant
  20. short acting testosterone products
    topical solution for hypogonadism
    axiron, fortestal
  21. long acting testosterone product in oil for injection - prodrugs
    • testosterone enanthate - andro LA
    • testosterone cypionate - depo testosterone
  22. treats endometriosis
    fibrocycstic breast disease
    hereditary angioderma

    inhibits pituitary gonadotropins
    danazol danocrine
  23. treats benign prostatic hyperplasia, androgenic alopecia
    inhibits 5 alpha reductase
    finasteride - propecia, proscar
  24. treats benign prostatic hyperplasia
    inhibits five alpha reductase
    dutasteride - avodart
  25. nonsteroid for BPH
    selective blockade of smooth muscle post-synaptic(alpha1) adrenergic receptors
    50% reduction in absorption without food - take immediately after eating
    extensive hepatic metabolism by CYP 3A4
    alfuzosin HCL - uroxatral
  26. nonsteroid for BPH
    selective blockade of smooth muscle post-synaptic(alpha1A) adrenergic receptors
    metabolized by CYP 3A4
    silodosin- rapaflo
  27. steroid used for anabolic activity
    promotes weight gain
    oxandrolone - oxandrin
  28. steroid used for anabolic activity
    indicated for anemia
    oxymetholone - anadrol
  29. steroid used for anabolic activity
    used for anemias of renal insufficiency (dialysis)
    oxandrolone decanoate - deca-durabolin
  30. steroid for hereditary angioedema
    stanoxzolol - winstrol
  31. steroid for hereditary angioedema
    protein product derived from human plasma C1 esterase inhibitors
    for prophylaxis
    cinryne
  32. steroid for hereditary angioedema protein product derived from human plasma C1 esterase inhibitors
    for acute attacks
    berinert
  33. for hereditory angiodema
    kallkrein inhibitor
    produced in pichia pastoris yeast
    ecallantide - kalbitor
  34. steroid for acute attacks of hereditary angioedem
    selectiv bradykinin B2 receptor antagonist which prevents incontrollable vascular permeability
    icatibant - firazyr
  35. non-steroid product for anemia
    very teratogenic, men must wrap also
    only 28 day supply
    for myelodysplastic syndrome
    inhibits cox 2
    lenalidomide - revlimid
  36. non-steroid that caused flipper babies
    now used for leprosy sometimes
    thalidomide
  37. abortifacients
    selective progesterone antagonist
    black box warning - may cause life threatening infection due to imcomplete abortion
    RU-486 mifepristone - mifeprex
  38. abortifacient
    stimulates violent uterine contractions
    carboprost tromethamine - hemabate (prostaglandin F2alpha
  39. agents for cervical ripening
    induces labor in conjunction with oxytocin
    dinoprostone - prepidil or cervidil (prostaglandin E2 or prostin E2)
  40. for cervical ripening via IV drip
    natural pituitary hormone that increases uterine contractions
    oxytocin - pitocin or syntocinon
  41. for post-partum or post abortal bleeding
    increase uterine contractions and decreasing bleeding
    will see in a hospital
    ergonovine maleate - ergotrate
  42. for post-partum or post abortal bleedingincrease uterine contractions and decreasing bleeding
    will see in the community pharmacy
    methylergonovine maleate - methergine
  43. uterine active agents
    injection
    management of pre-term labor
    B2-receptor agonist that decreases uterine smooth muscle contractions
    ritodrine - yutopar
  44. first bisphosphonates developed for mineralization inhibition
    etidronate
  45. These are incorporated into the bone matrix and is imbibed by osteoclasts. This incapacitates the osteoclast preventing resorption of the bone. You take them at least 90 minutes before or after meals and only with water.
    avoid Al or Mg containing antacids
    bisphosphonates
  46. first generation bisphosphonate
    etidronate - didronel
  47. name 2, 1.5 generation bisphophonates
    • pamidronate - aredia
    • alendronate - fosamax
  48. second generation bisphosphonate
    tiludronate sodium - skelid
  49. 3rd generation bishposphonate
    available with CaCO3 but taken on different days to avoid kelation
    risedronate sodium - actonel
  50. 3rd generation bisphosphonate
    for hypercalcemia due to malignancy
    zoledronic acid - zometa
  51. 3rd generation bisphosphonate
    IV administration once yearly for osteoporosis, paget's disease
    zoledronic acid - reclast
  52. 3rd generation bisphosphonate for postmenopausal osterporosis
    renal clearance is linearly related to creatinine clearance
    ibandronate sodium - boniva
  53. bad side effect of bisphosphonate in the jaw
    osteonecrosis
  54. bad side effect of bisphosphonate when you dissolve it behind your denture
    stomatitis
  55. new treatment of osteoporosis
    for both men and women
    recombinant human parathyroid hormone
    actually stimulates new bone formation
    rats get osteosarcoma
    teriparatide (rDNA origin) injection - forteo
  56. for postmenopausal women with osteoporosis
    RANK inhibitor
    human IgG2 monoclonal antibody
    denosumab - prolia
  57. human IgG2 monoclonal antibody
    prevention of skeletal related events such as pathological fracture
    denosumab - Xgeva
  58. treatment of sceondary hyperparathyroidism dialysis patient with chronic kidney disease
    increases the sensitivity of the Ca2+ sensing receptor on parathyroid gland
    enantiopure drug - only R is active
    cinacalcet HCL - sensipar
  59. What is the major mineralocorticoid
    aldosterone
  60. What is the major endogenous glucocorticoid
    cortisol
  61. This disease is primary adrenocortical insufficiency- require replacement therapy of both glucocorticoid and mineralcorticoids

    Secondary adrenocortical insufficiency due to inadequate ACTH secretion
    addison's
  62. Diagnostic test of pituitary adrenocorticotropic function
    metopirone - metyrapone
  63. This disease is caused by excessive secretion of glucocorticoids as a result of excessive ACTH secretion or a primary adrenal source such as a benign adenoma or a carcinoma
    Best treatment is surgical
    cushing's
  64. Prolonged treatment with glucocorticoids can lead to what
    iatrogenic cushings
  65. This prevents the conversion of cholesterol to pregnenolone
    adrenal steroid inhibitor
  66. adrenal steroid inhibitor
    cushing's syndrome and postmenopausal patients with advanced breast and prostrate carcinoma
    aminogluethimide - cytadren
  67. Treatment of cushing's syndrome
    antagonist of one of the body's two cortisol receptors and progesterone receptor
    useful in treating psychosis and depression associated with cushing's
    RU-486 mifepristone - corlux
  68. oxidized cortisol
    cortisone - cortone acetate
  69. The only mineralcorticoid product for primary or secondary adrenal insufficiency, management of severe orthostatic hypotension
    fludrocortisone acetate
  70. nonsteroidal immune response modulator
    for rheumatoid arthritis
    inhibits dihydroorotate dehydrogenase
    contraindicated in pregnancy, contraception is absolutely required
    inhibits CYP2C9
    leflunomide - arava
  71. growth hormone powder for injection
    sometrem - protropin
  72. growth hormone injection
    somatropin - humatrope, nutropin
  73. New growth hormone agent
    recombinant insulin-like growth factor-1
    treatment of growth failure in children
    mesasermin - increlex
  74. posterior pituitary hormone product
    for acromegaly, severe diarrhea, hypoglycemia due to excess insulin
    add a D amino acid
    octreotide acetate - sandostatin
  75. hormone analog for acromegaly
    long-term treatment
    stops tissue growth
    somatuline depot (lanreotide)
  76. Used for postmenopausal osteoporosis
    isolated from salmon
    suppresses resorption of bone by inhibiting the activity of osteoclasts
    injection and nasal spray
    calcitonin salmon - miacalcin
  77. Used in cancer related hypercalcemia
    gallium nitrate - ganite
  78. used in homocystinuria due to elevated blood levels - acts as a methyl donor to produce methionine
    betaine anhydrous - cystadane
  79. management of nephropathic cystinosis, a systine depleting agent
    cysteamine bitartrate
  80. treats euvolemic hyponatremia
    antagonist of arginine vasopressin
    excretetion of free water
    99% protein bound
    metabolized by CYP3A4
    conivaptan HCL - vaprisol
  81. hypervolemic and euvolemic hyponatremia
    oral selective vasopressin-receptor antagonist
    metabolized by CYP3A4 and is a p-glycoprotein substrate
    tolvaptan - samsca

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